{"id":"W4310592251","doi":"10.1016/j.celrep.2022.111726","title":"The ribosomal RNA processing 1B:protein phosphatase 1 holoenzyme reveals non-canonical PP1 interaction motifs","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Argonne National Laboratory; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Office of Science; U.S. Department of Energy","keywords":"Ribosome biogenesis; Protein phosphatase 1; Biology; Phosphatase; Phosphorylation; Cell biology; Nucleolus; Ribosomal protein; RNA-binding protein; Biogenesis; Ribosome; Biochemistry; Serine; RNA; Gene; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007636186,0.0001335269,0.0001200155,0.00002749302,0.0006779553,0.00009095004,0.0002002845,0.00006139762,0.00005901564],"category_scores_gemma":[0.0001786221,0.0001075736,0.0000970657,0.0001148385,0.00006937978,0.000008426511,0.0003543431,0.0003130996,0.00000656059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006009451,"about_ca_system_score_gemma":0.0002488672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005448874,"about_ca_topic_score_gemma":0.000009588006,"domain_scores_codex":[0.9983699,0.00009886406,0.000380566,0.0004292887,0.0003293378,0.0003920815],"domain_scores_gemma":[0.9990157,0.00001565274,0.0002582278,0.000503469,0.00007416864,0.0001327999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001137771,0.00009330889,0.0006029789,0.00002147435,0.00001333638,0.0004310937,0.00002187751,0.0001214336,0.9837605,0.00000497971,0.008675897,0.006139396],"study_design_scores_gemma":[0.0002840734,0.0002667555,0.0005916472,0.00001733129,0.000009552772,0.0003846381,0.0002170114,0.0003921494,0.8983356,0.00006138839,0.09925619,0.0001836578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946347,0.00210349,0.0002292714,0.0002170549,0.0002255791,0.0003346408,0.00000685631,0.0000138482,0.002234494],"genre_scores_gemma":[0.9873408,0.00004334301,0.0001215365,0.0001161991,0.0001824442,0.0001459814,0.0001165993,0.00002552424,0.01190757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09058029,"threshold_uncertainty_score":0.5214353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003718854925115,"score_gpt":0.2668184936745568,"score_spread":0.2567813051253057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}