{"id":"W4310592251","doi":"10.1016/j.celrep.2022.111726","title":"The ribosomal RNA processing 1B:protein phosphatase 1 holoenzyme reveals non-canonical PP1 interaction motifs","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Argonne National Laboratory; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Office of Science; U.S. Department of Energy","keywords":"Ribosome biogenesis; Protein phosphatase 1; Biology; Phosphatase; Phosphorylation; Cell biology; Nucleolus; Ribosomal protein; RNA-binding protein; Biogenesis; Ribosome; Biochemistry; Serine; RNA; Gene; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001803575,0.0003656686,0.0001976439,0.0001037858,0.0001322128,0.0004327422,0.0001837501,0.0002840201,0.000775083],"category_scores_gemma":[0.0001092048,0.0001729938,0.0001368255,0.00009590339,0.0001884185,0.0001672228,0.0002041216,0.0003781008,0.0007032111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003038218,"about_ca_system_score_gemma":0.0001566458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002567236,"about_ca_topic_score_gemma":0.0005965343,"domain_scores_codex":[0.9999049,0.00001739208,0.00000619616,0.00003241411,0.00002451849,0.00001451846],"domain_scores_gemma":[0.9999384,0.000007745186,0.00001749728,0.000005067834,0.000005267914,0.00002600326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009828451,0.00001036797,0.0002903059,0.00002882131,0.000004149555,0.0001232409,0.000006854631,0.00005184488,0.9980725,0.0002291613,0.00006876281,0.001015642],"study_design_scores_gemma":[0.00003846912,0.0001316882,0.01547275,0.000007788549,0.00001926808,0.002303994,0.00002096327,0.002526028,0.9713631,0.0003544535,0.007752535,0.000008993817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838424,0.004952578,0.008065063,0.000313423,0.00004888017,0.00001192874,0.0002766774,0.0001727316,0.002316287],"genre_scores_gemma":[0.9893661,0.001185827,0.00578642,0.0001027158,0.0000282125,0.00001364245,0.0006329831,0.000043863,0.002840213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000775083,"threshold_uncertainty_score":0.002592862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003718854925115,"score_gpt":0.2668184936745568,"score_spread":0.2567813051253057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}