{"id":"W4310593165","doi":"10.1038/s41590-022-01348-2","title":"Fungal sensing by dectin-1 directs the non-pathogenic polarization of TH17 cells through balanced type I IFN responses in human DCs","year":2022,"lang":"en","type":"article","venue":"Nature Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Universität Ulm","keywords":"IRF1; Biology; Cell biology; Transforming growth factor; Interferon; Transcription factor; Cytokine; Signal transduction; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001324703,0.0001751679,0.0001711449,0.0001063829,0.00009045161,0.0003321632,0.00005781924,0.0001777861,0.001461207],"category_scores_gemma":[0.00009218453,0.0001076306,0.00015082,0.00005871079,0.00009636376,0.00009498515,0.0001527021,0.0005237759,0.0004152885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001620317,"about_ca_system_score_gemma":0.0001597774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002356722,"about_ca_topic_score_gemma":0.0002864485,"domain_scores_codex":[0.9998612,0.00002831041,0.00001222076,0.00002767526,0.00002292907,0.00004754163],"domain_scores_gemma":[0.9999478,0.000009050463,0.00001058256,0.000008381734,0.000008018526,0.0000161884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001789747,0.00004323321,0.0005794145,0.00003766009,0.00000280763,0.0001005283,0.00002133863,0.00003505813,0.9967999,0.00008097111,0.00009458243,0.002025442],"study_design_scores_gemma":[0.00006231571,0.0005301209,0.009649157,0.00001781975,0.00001894566,0.0008682945,0.0001068146,0.001063479,0.9824604,0.0001278319,0.005089988,0.000004818966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943414,0.001544673,0.001259278,0.0001340501,0.00005147998,0.00003846626,0.0003014296,0.00003793319,0.002291279],"genre_scores_gemma":[0.9973226,0.0005569709,0.0006845439,0.00008495016,0.00001556872,0.00001805008,0.0001915285,0.000005538801,0.001120142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001461207,"threshold_uncertainty_score":0.004888237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006754519249356988,"score_gpt":0.2408461236929596,"score_spread":0.2340916044436026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}