{"id":"W4310595457","doi":"10.1093/brain/awac446","title":"Neurodevelopmental effects of genetic frontotemporal dementia in young adult mutation carriers","year":2022,"lang":"en","type":"article","venue":"Brain","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Toronto Western Hospital; Université Laval; University of Toronto; Sunnybrook Health Science Centre; Western University","funders":"NIHR Cambridge Biomedical Research Centre; UCLH Biomedical Research Centre; Medical Research Council; UK Dementia Research Institute; Ministero della Salute; Brain Research UK; Deutsche Forschungsgemeinschaft; Wolfson Foundation; Wellcome Trust; Alzheimer's Society; Agence Nationale de la Recherche; University College London; EU Joint Programme – Neurodegenerative Disease Research; National Institute for Health and Care Research; Canadian Institutes of Health Research; Alzheimer’s Society","keywords":"Frontotemporal dementia; C9orf72; Dementia; Psychology; Frontotemporal lobar degeneration; Disease; Medicine; Neuroscience; Oncology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003201985,0.0003298381,0.0003344485,0.0007816807,0.0003791786,0.0003587633,0.0001534914,0.0003740812,0.001441764],"category_scores_gemma":[0.001500844,0.0001271733,0.0001902767,0.0002741009,0.0002417877,0.0001962494,0.0002575211,0.0001875725,0.0002171014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002607213,"about_ca_system_score_gemma":0.0002870092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007789325,"about_ca_topic_score_gemma":0.007665468,"domain_scores_codex":[0.9998896,0.00001994744,0.00001160073,0.00002707192,0.00001962742,0.00003210844],"domain_scores_gemma":[0.999542,0.0001070327,0.0001501453,0.00001616143,0.00005292068,0.0001318253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002209619,0.0003268977,0.9323505,0.0000556512,0.0001119418,0.02432679,0.001599369,0.0001568781,0.0238903,0.0001628896,0.000373058,0.01443611],"study_design_scores_gemma":[0.00001332252,0.0007247207,0.9928018,0.00001333279,0.00003666443,0.004805181,0.0003824087,0.00007927376,0.0007839717,0.00008752641,0.0002643301,0.000007664423],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996054,0.0001203484,0.00001037925,0.00001055928,0.000002480699,0.00000201006,0.00006403986,0.000001795969,0.0001829211],"genre_scores_gemma":[0.999513,0.0001124763,0.00004113133,0.00001423189,0.000003640316,0.000003344704,0.00009721243,0.000002018698,0.0002128905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007789325,"threshold_uncertainty_score":0.01548797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008181239315771817,"score_gpt":0.2539476644621855,"score_spread":0.2457664251464137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}