{"id":"W4310595457","doi":"10.1093/brain/awac446","title":"Neurodevelopmental effects of genetic frontotemporal dementia in young adult mutation carriers","year":2022,"lang":"en","type":"article","venue":"Brain","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Toronto Western Hospital; Université Laval; University of Toronto; Sunnybrook Health Science Centre; Western University","funders":"NIHR Cambridge Biomedical Research Centre; UCLH Biomedical Research Centre; Medical Research Council; UK Dementia Research Institute; Ministero della Salute; Brain Research UK; Deutsche Forschungsgemeinschaft; Wolfson Foundation; Wellcome Trust; Alzheimer's Society; Agence Nationale de la Recherche; University College London; EU Joint Programme – Neurodegenerative Disease Research; National Institute for Health and Care Research; Canadian Institutes of Health Research; Alzheimer’s Society","keywords":"Frontotemporal dementia; C9orf72; Dementia; Psychology; Frontotemporal lobar degeneration; Disease; Medicine; Neuroscience; Oncology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001478702,0.00007453526,0.0001476884,0.0001200948,0.00005220768,0.000004870256,0.00008136908,0.0000239285,0.000231085],"category_scores_gemma":[0.0001424536,0.00007460713,0.00003664671,0.0002227074,0.00003604786,0.00003577603,0.000102564,0.0001666585,0.000005070923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001776801,"about_ca_system_score_gemma":0.0001111018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001237338,"about_ca_topic_score_gemma":0.0001710437,"domain_scores_codex":[0.9988123,0.0001551234,0.0002182008,0.0001808989,0.0004324059,0.0002011087],"domain_scores_gemma":[0.9996931,0.00004319863,0.00004908367,0.0001163723,0.00002883098,0.00006943201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001585992,0.00009818843,0.9452672,0.0001217306,0.00004332192,0.0002565217,0.001589681,0.0001094592,0.04589007,0.0000198858,0.001191482,0.005253858],"study_design_scores_gemma":[0.002010744,0.000301635,0.9958426,0.00002736802,0.00001209318,0.00003093711,0.0001570023,0.000895466,0.0005584196,0.00003311367,0.00006642741,0.00006419174],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982266,0.000116077,0.00005802543,0.0007146619,0.0001237549,0.0004848775,0.00000456015,0.0000148502,0.0002565808],"genre_scores_gemma":[0.9984959,0.000005424454,0.0008045225,0.0003050872,0.00001909955,0.00008675358,0.00002997267,0.00001613696,0.0002370716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05057541,"threshold_uncertainty_score":0.304239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008181239315771817,"score_gpt":0.2539476644621855,"score_spread":0.2457664251464137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}