{"id":"W4310603204","doi":"10.1016/j.ymthe.2022.11.010","title":"Cellular therapy: Great promise, but at what cost?","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Toronto General Hospital","funders":"","keywords":"Chimeric antigen receptor; Medicine; Mantle cell lymphoma; Lymphoma; Follicular lymphoma; Cancer research; Oncology; Immunotherapy; Immunology; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006691923,0.000388462,0.0005126251,0.0002538903,0.0004425443,0.0001295055,0.0004614593,0.0001166907,0.03882405],"category_scores_gemma":[0.00001530338,0.0003513832,0.0004299766,0.0005768487,0.0001500066,0.0001352619,0.0002517321,0.0006393431,0.0002169269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006035537,"about_ca_system_score_gemma":0.0002051432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005272839,"about_ca_topic_score_gemma":0.000002326497,"domain_scores_codex":[0.9962848,0.0004601478,0.0003540261,0.0007277769,0.001418403,0.0007548876],"domain_scores_gemma":[0.9981206,0.00006472741,0.0000993738,0.001261131,0.0001329981,0.0003211794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003207955,0.0003645891,0.0005510415,0.00001302756,0.0003167469,0.001053147,0.0006352779,0.00003109673,0.8316501,0.00005447428,0.001304734,0.1608178],"study_design_scores_gemma":[0.005649475,0.001101421,0.0001865209,0.00001452077,0.00001443775,0.0001648925,0.0002383622,0.0000946756,0.5217102,0.0001543256,0.4704105,0.000260666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9604656,0.02825461,0.000138011,0.003278327,0.0003818445,0.003016666,0.00001637114,0.0001872513,0.004261292],"genre_scores_gemma":[0.8755212,0.01603202,0.0002696361,0.01219798,0.0003435034,0.002011821,0.0003652948,0.0004026121,0.09285595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4691058,"threshold_uncertainty_score":0.9998938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0356913478571717,"score_gpt":0.2970016840412436,"score_spread":0.2613103361840718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}