{"id":"W4310603204","doi":"10.1016/j.ymthe.2022.11.010","title":"Cellular therapy: Great promise, but at what cost?","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Toronto General Hospital","funders":"","keywords":"Chimeric antigen receptor; Medicine; Mantle cell lymphoma; Lymphoma; Follicular lymphoma; Cancer research; Oncology; Immunotherapy; Immunology; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01454555,0.001437139,0.002835311,0.001178856,0.001265924,0.007272372,0.002220867,0.009121909,0.03900239],"category_scores_gemma":[0.01353486,0.0004521038,0.00176358,0.0008663991,0.006666553,0.01247131,0.002140767,0.009531634,0.007970982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002818939,"about_ca_system_score_gemma":0.007371423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002390184,"about_ca_topic_score_gemma":0.005358638,"domain_scores_codex":[0.995954,0.001818663,0.0002084657,0.000435387,0.001016337,0.0005671066],"domain_scores_gemma":[0.9831684,0.0102475,0.0008308597,0.0007625546,0.002750001,0.002240625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002340426,0.0006966494,0.002120132,0.004426803,0.000449529,0.001130334,0.0003212555,0.001210819,0.006681914,0.1013738,0.3268335,0.5524148],"study_design_scores_gemma":[0.0006963923,0.001821914,0.003244889,0.005368856,0.000546456,0.002433199,0.002761476,0.001446554,0.003873089,0.121435,0.8561856,0.0001865073],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.00334007,0.3691515,0.003957865,0.6007433,0.008232141,0.00006991116,0.0004041687,0.0002559806,0.01384513],"genre_scores_gemma":[0.09318137,0.634298,0.01474227,0.1803522,0.04693627,0.0003895961,0.0008429051,0.0002151265,0.02904233],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03900239,"threshold_uncertainty_score":0.130476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0356913478571717,"score_gpt":0.2970016840412436,"score_spread":0.2613103361840718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}