{"id":"W4310617790","doi":"10.1016/j.jaut.2022.102961","title":"Flagellin-specific human CAR Tregs for immune regulation in IBD","year":2022,"lang":"en","type":"article","venue":"Journal of Autoimmunity","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Crohn's and Colitis Canada; University of British Columbia; Canadian Institutes of Health Research; Mitacs; National Institutes of Health; Michael Smith Health Research BC","keywords":"Flagellin; Immune system; Immunology; Medicine; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006410167,0.0003870447,0.0004420952,0.0003265186,0.0003238268,0.0005464851,0.0003689227,0.0005454378,0.003986316],"category_scores_gemma":[0.0003210045,0.0002512316,0.0003431093,0.0001363527,0.0002683222,0.0003423264,0.0003324464,0.002062138,0.0006794391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00038835,"about_ca_system_score_gemma":0.0004132923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005179825,"about_ca_topic_score_gemma":0.001381149,"domain_scores_codex":[0.9996666,0.00009202791,0.00001622106,0.00004403948,0.00004155958,0.000139535],"domain_scores_gemma":[0.9998778,0.00003944075,0.00001348423,0.00002715916,0.00001275666,0.00002931821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002760964,0.0006590085,0.0006399066,0.000186337,0.00002221383,0.0001983388,0.0001260116,0.0009125812,0.9711548,0.001302446,0.000884079,0.02115329],"study_design_scores_gemma":[0.001597372,0.00558617,0.006978625,0.0001042198,0.0001849457,0.001716797,0.0002330929,0.009457783,0.9456598,0.0009209383,0.02752264,0.00003750613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834363,0.005278105,0.005291522,0.0003669856,0.0002221659,0.0002100932,0.0003035284,0.000339053,0.004552207],"genre_scores_gemma":[0.9948443,0.0007698337,0.001715379,0.00011441,0.00004929609,0.00009090092,0.0002543245,0.00003724991,0.002124197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003986316,"threshold_uncertainty_score":0.01333559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02419354151414097,"score_gpt":0.2578036598669894,"score_spread":0.2336101183528484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}