{"id":"W4310641961","doi":"10.1139/cjpp-2022-0265","title":"Influence of permeability enhancers on the paracellular permeability of metformin hydrochloride and furosemide across Caco-2 cells","year":2022,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hacettepe Üniversitesi","keywords":"Paracellular transport; Permeability (electromagnetism); Chemistry; Furosemide; Pharmacology; Caco-2; Intestinal permeability; In vitro; Medicine; Internal medicine; Biochemistry; Membrane","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002354637,0.0002584702,0.000707878,0.0001513072,0.0006678883,0.000003896376,0.0005199371,0.0002119019,0.001585347],"category_scores_gemma":[0.000157933,0.000214532,0.0001461814,0.000234452,0.002158954,0.0001274893,0.0001330966,0.001483772,0.000002980956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001866995,"about_ca_system_score_gemma":0.0005789777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006078512,"about_ca_topic_score_gemma":0.0002427357,"domain_scores_codex":[0.9963444,0.0017503,0.0008601151,0.0003364423,0.0001486257,0.0005600891],"domain_scores_gemma":[0.9964224,0.001791507,0.0008606858,0.0002263885,0.0002489682,0.0004500621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009818539,0.0001048779,0.003917838,0.0001591563,0.000253707,0.00005599826,0.003871917,0.05152478,0.9376498,0.0002496796,0.0005361278,0.0006942846],"study_design_scores_gemma":[0.001478477,0.001181108,0.005408395,0.00001338989,0.0001989196,0.0002365601,0.001517585,0.0008179844,0.9649705,0.001435655,0.0225071,0.000234322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954944,0.001966826,0.000005246172,0.0005637438,0.001158643,0.0004174596,0.0003158883,0.000005060119,0.00007269538],"genre_scores_gemma":[0.9979962,0.0003257464,0.00001498358,0.001423048,0.0001247931,0.00002967363,0.000004493114,0.000016547,0.00006451247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05070679,"threshold_uncertainty_score":0.9993274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04208794624724065,"score_gpt":0.3588490807238927,"score_spread":0.3167611344766521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}