{"id":"W4310668116","doi":"10.1016/j.bpj.2022.11.2945","title":"Geometric differences in the ribosome exit tunnel impact the escape of small nascent proteins","year":2022,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia","keywords":"Eukaryote; Ribosome; Folding (DSP implementation); Translation (biology); Physics; Protein folding; Biophysics; Geometry; Biology; RNA; Mathematics; Genetics; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006161668,0.0001320209,0.000167759,0.0001109253,0.0002485375,0.00004427268,0.0007232208,0.0000445169,0.00009079879],"category_scores_gemma":[0.00006389316,0.00006585601,0.0002388445,0.0004999328,0.0000698029,0.000003118293,0.000162941,0.0003033143,0.000003052654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001803088,"about_ca_system_score_gemma":0.00006582509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003759568,"about_ca_topic_score_gemma":0.000003275754,"domain_scores_codex":[0.9985588,0.0004390668,0.0002393572,0.0001603502,0.0003558521,0.0002465959],"domain_scores_gemma":[0.9994195,0.00004611957,0.0001763617,0.0002679016,0.000036433,0.00005365319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001177426,0.0002910915,0.001240798,0.00000526244,0.00004684968,0.000009377783,0.000114885,0.0000387926,0.9950105,0.0001627867,0.0001829403,0.002778976],"study_design_scores_gemma":[0.001206323,0.004239345,0.1678194,0.00003384585,0.00006356007,0.0003761593,0.001389125,0.0001861221,0.819019,0.001850102,0.003364906,0.0004521929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980761,0.0003385377,0.0005743494,0.000519796,0.0001085938,0.0002678196,0.00001946608,0.000002129615,0.00009324466],"genre_scores_gemma":[0.9991574,0.0001421077,0.0001141972,0.0001374141,0.0003276804,0.00005975292,0.000004627837,0.00001030044,0.00004651338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1759916,"threshold_uncertainty_score":0.268553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.023759565993475,"score_gpt":0.246841046959851,"score_spread":0.223081480966376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}