{"id":"W4310676081","doi":"10.1016/j.omtn.2022.11.024","title":"Formulation, inflammation, and RNA sensing impact the immunogenicity of self-amplifying RNA vaccines","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"Biotechnology and Biological Sciences Research Council; Coalition for Epidemic Preparedness Innovations","keywords":"Immunogenicity; RNA; Inflammation; Virology; Immunology; Medicine; Biology; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002922737,0.0001741307,0.0001571708,0.00005514983,0.0003107856,0.0000359179,0.0002404955,0.00006569171,0.00004979967],"category_scores_gemma":[0.0000207301,0.0001361147,0.0001534582,0.0001486349,0.00003334678,0.00001026407,0.0001954951,0.0001198649,0.000001599994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002602373,"about_ca_system_score_gemma":0.00005889376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006736286,"about_ca_topic_score_gemma":0.000003773665,"domain_scores_codex":[0.99895,0.0001423722,0.0002778648,0.0002450755,0.0001869772,0.00019768],"domain_scores_gemma":[0.9992281,0.00001398828,0.0001650426,0.0004262774,0.0001294536,0.00003717767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001677009,0.00002128567,0.00151972,0.000005754186,0.000230706,0.000002509996,0.0004482346,0.0007534018,0.9851924,0.00005073443,0.00009703587,0.01151048],"study_design_scores_gemma":[0.0008826276,0.0005318459,0.009042531,0.000006952989,0.00003105574,0.00005595358,0.0002897837,0.001167778,0.9833198,0.000454825,0.00398489,0.0002319635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942251,0.002514174,0.002572504,0.000206114,0.00007512735,0.0002377906,0.00001162746,0.00001776904,0.0001397931],"genre_scores_gemma":[0.9987283,0.0004122502,0.0004018769,0.0002682481,0.00006977583,0.00001015771,0.00005100415,0.0000285374,0.00002980509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01127852,"threshold_uncertainty_score":0.5550596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009316087565917562,"score_gpt":0.2467243162510996,"score_spread":0.2374082286851821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}