{"id":"W4310702751","doi":"10.1093/nar/gkac1103","title":"Response regulator PorX coordinates oligonucleotide signalling and gene expression to control the secretion of virulence factors","year":2022,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"European Social Fund; National Institute of Dental and Craniofacial Research; Politechnika Wrocławska; Narodowym Centrum Nauki; Generalitat de Catalunya; European Synchrotron Radiation Facility; Ministerio de Ciencia, Innovación y Universidades","keywords":"Biology; Effector; Response regulator; Phosphatase; Secretion; Mutagenesis; Gene; Genetics; Cell biology; Virulence; Oligonucleotide; Regulator; Biochemistry; Mutation; Phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002266702,0.0001149881,0.0001470319,0.000118748,0.000452751,0.00002869895,0.0004127931,0.00006461487,0.0001045329],"category_scores_gemma":[0.0005687129,0.00008863888,0.00005649817,0.0002596684,0.0002178554,0.000006982303,0.0005242877,0.0002197732,0.000003506957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000175016,"about_ca_system_score_gemma":0.00008537862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005042113,"about_ca_topic_score_gemma":0.000002221142,"domain_scores_codex":[0.9977295,0.0008778846,0.0001942993,0.000351812,0.0005154337,0.0003310597],"domain_scores_gemma":[0.9991359,0.000151146,0.00005901929,0.000386956,0.0001436188,0.00012333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00168358,0.00003808354,0.004706102,0.000008884283,0.00001472003,0.00000191026,0.000290882,0.0003500236,0.9909585,0.00006873807,0.00142752,0.0004510346],"study_design_scores_gemma":[0.000786496,0.0006302272,0.04104064,0.00001241508,0.000008857115,0.000005639779,0.002060441,0.0002408544,0.932675,0.0002535641,0.02212636,0.000159522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971398,0.001051232,0.0006395206,0.0005663884,0.00005170046,0.0003603129,0.00007048902,0.000008562783,0.0001120157],"genre_scores_gemma":[0.9990588,0.0001007393,0.0002516254,0.0001643011,0.0000425633,0.00004667173,0.00002192838,0.00002241312,0.0002909963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05828354,"threshold_uncertainty_score":0.3614589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01882618035243229,"score_gpt":0.2925241569090297,"score_spread":0.2736979765565974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}