{"id":"W4310709313","doi":"10.1016/j.neubiorev.2022.104965","title":"Effectiveness of pharmacogenomic tests including CYP2D6 and CYP2C19 genomic variants for guiding the treatment of depressive disorders: Systematic review and meta-analysis of randomised controlled trials","year":2022,"lang":"en","type":"review","venue":"Neuroscience & Biobehavioral Reviews","topic":"Treatment of Major Depression","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"United Arab Emirates University","keywords":"Pharmacogenomics; Meta-analysis; CYP2C19; CYP2D6; Randomized controlled trial; Psychology; Clinical psychology; Medicine; Psychiatry; Bioinformatics; Pharmacology; Genetics; Internal medicine; Biology; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","metaepi_broad"],"consensus_categories":[],"category_scores_codex":[0.01062184,0.0008560048,0.03365466,0.0005853649,0.0001926875,0.00002852473,0.0004355875,0.0001191086,0.00007725427],"category_scores_gemma":[0.005174216,0.0003793443,0.007724049,0.001028218,0.0003065158,0.00009637044,0.000179851,0.000119387,3.63204e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001830609,"about_ca_system_score_gemma":0.0002052674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003384898,"about_ca_topic_score_gemma":0.000001614199,"domain_scores_codex":[0.9873651,0.006183926,0.004658956,0.0009542964,0.0005296446,0.0003080895],"domain_scores_gemma":[0.9883014,0.002276033,0.008118881,0.001044033,0.0001144428,0.0001451847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001138815,0.001175417,0.00005233111,0.8714259,0.007802537,0.000008834086,0.0001041465,0.000001594121,0.00913401,0.000006465006,0.000009552789,0.1091404],"study_design_scores_gemma":[0.01308062,0.00103353,0.00002961901,0.0290039,0.9405274,0.0000281642,0.0000062595,0.00001510281,0.00006505845,0.000001987067,0.01597785,0.000230505],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00081092,0.9427045,0.0000295007,0.000005420249,0.00009400774,0.05583807,0.0005027417,0.00001018827,0.000004667627],"genre_scores_gemma":[0.002018574,0.983099,0.00009812471,0.00003500802,0.000008662159,0.01460871,0.00005760699,0.00004850611,0.00002581852],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9327249,"threshold_uncertainty_score":0.9998658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4318064648370188,"score_gpt":0.4922162009097147,"score_spread":0.06040973607269595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}