{"id":"W4310709313","doi":"10.1016/j.neubiorev.2022.104965","title":"Effectiveness of pharmacogenomic tests including CYP2D6 and CYP2C19 genomic variants for guiding the treatment of depressive disorders: Systematic review and meta-analysis of randomised controlled trials","year":2022,"lang":"en","type":"review","venue":"Neuroscience & Biobehavioral Reviews","topic":"Treatment of Major Depression","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"United Arab Emirates University","keywords":"Pharmacogenomics; Meta-analysis; CYP2C19; CYP2D6; Randomized controlled trial; Psychology; Clinical psychology; Medicine; Psychiatry; Bioinformatics; Pharmacology; Genetics; Internal medicine; Biology; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01012451,0.002890808,0.02090386,0.00319206,0.0004412988,0.002681673,0.002212102,0.002499065,0.003772464],"category_scores_gemma":[0.02573833,0.00115658,0.03163588,0.003747164,0.0008789632,0.001580008,0.001425487,0.002823995,0.0002672032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001734935,"about_ca_system_score_gemma":0.002245537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00499707,"about_ca_topic_score_gemma":0.01003621,"domain_scores_codex":[0.9939767,0.002883831,0.001513596,0.000810229,0.0006426469,0.000172932],"domain_scores_gemma":[0.9837053,0.01363602,0.001618258,0.0003680592,0.0005271335,0.0001452442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.007702218,0.00006420593,0.002047025,0.3292978,0.6235625,0.00007897329,0.00006444973,0.0007089062,0.0003494195,0.0001933487,0.0006856805,0.0352456],"study_design_scores_gemma":[0.002720019,0.0004212713,0.002633166,0.01755483,0.9742725,0.00006952068,0.00003807083,0.0001812249,0.0001363324,0.0003202291,0.001621197,0.00003166744],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003000184,0.995903,0.0003711469,0.0001156597,0.0001213449,0.0001178279,0.0002279285,0.00001436256,0.0001286327],"genre_scores_gemma":[0.1136884,0.8818514,0.002107688,0.0009158541,0.0002554875,0.000329456,0.0005783584,0.00002559626,0.0002476271],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02090386,"threshold_uncertainty_score":0.05354416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4318064648370188,"score_gpt":0.4922162009097147,"score_spread":0.06040973607269595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}