{"id":"W4310709948","doi":"10.1016/j.jcmgh.2022.11.010","title":"HNF4α Acts as Upstream Functional Regulator of Intestinal Wnt3 and Paneth Cell Fate","year":2022,"lang":"en","type":"article","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Génome Québec; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"LGR5; Wnt signaling pathway; Paneth cell; Cell biology; Intestinal epithelium; Biology; Stem cell; Mesenchymal stem cell; Transcriptome; Intestinal mucosa; Cellular differentiation; Ex vivo; Epithelium; Signal transduction; In vivo; Small intestine; Genetics; Gene expression; Endocrinology; Internal medicine; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000174532,0.0001751528,0.0004448577,0.00013187,0.0001243699,0.000005066175,0.00004632655,0.00007967518,0.0002836838],"category_scores_gemma":[0.00001505948,0.0001707768,0.00007129044,0.00005032526,0.0003665304,0.00002014391,0.0002060386,0.0002696394,0.00000158618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001567633,"about_ca_system_score_gemma":0.00005069732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005223462,"about_ca_topic_score_gemma":0.00001258241,"domain_scores_codex":[0.9987935,0.0001581369,0.0002460968,0.0003861202,0.0001191366,0.0002969707],"domain_scores_gemma":[0.9994609,0.0000302035,0.0001153746,0.0001731935,0.00004015976,0.0001801803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005189348,0.0004839228,0.5129862,0.0004052871,0.0003476992,0.001284817,0.000423966,0.00001158365,0.4716697,0.002813926,0.000953133,0.003430471],"study_design_scores_gemma":[0.03667628,0.03460105,0.1680216,0.0001415503,0.004251715,0.04981964,0.002690567,0.001475597,0.5876353,0.004338768,0.109155,0.001192948],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944412,0.0026927,0.001047937,0.001009503,0.0001559403,0.0001804608,0.00001928241,0.00001328137,0.0004396823],"genre_scores_gemma":[0.9972026,0.0003782906,0.0004492063,0.001583035,0.00002510788,0.00001857752,0.00007166848,0.0000163659,0.0002551642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3449646,"threshold_uncertainty_score":0.6964075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009022672279460913,"score_gpt":0.2155052244248679,"score_spread":0.206482552145407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}