{"id":"W4310709948","doi":"10.1016/j.jcmgh.2022.11.010","title":"HNF4α Acts as Upstream Functional Regulator of Intestinal Wnt3 and Paneth Cell Fate","year":2022,"lang":"en","type":"article","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Génome Québec; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"LGR5; Wnt signaling pathway; Paneth cell; Cell biology; Intestinal epithelium; Biology; Stem cell; Mesenchymal stem cell; Transcriptome; Intestinal mucosa; Cellular differentiation; Ex vivo; Epithelium; Signal transduction; In vivo; Small intestine; Genetics; Gene expression; Endocrinology; Internal medicine; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001232782,0.0004267401,0.0002311057,0.0003522352,0.0002133444,0.0002514942,0.0001526888,0.0002181786,0.001793634],"category_scores_gemma":[0.0001424461,0.0001325047,0.0003173684,0.0001563126,0.000274401,0.000177312,0.0002238981,0.0002905864,0.000399586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005446736,"about_ca_system_score_gemma":0.0003112179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001566931,"about_ca_topic_score_gemma":0.001830267,"domain_scores_codex":[0.9998362,0.00002134081,0.000009714926,0.00003880889,0.00004434165,0.00004953301],"domain_scores_gemma":[0.999895,0.00001246936,0.00003513065,0.0000130581,0.00001756406,0.00002684434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001783907,0.000008859747,0.0009529532,0.00003688229,0.000006344439,0.00008105323,0.000009063824,0.00005797432,0.9972058,0.00007801833,0.00004452814,0.001340096],"study_design_scores_gemma":[0.0000160434,0.0001130861,0.02696109,0.00001349699,0.00002318243,0.0003989238,0.00006102341,0.001005336,0.9671661,0.0001021583,0.004134165,0.0000053813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986389,0.003750403,0.005582843,0.0001254295,0.00004196396,0.00004123685,0.001193723,0.0001645306,0.002710936],"genre_scores_gemma":[0.9900468,0.0009819706,0.002761101,0.00005765096,0.0000105813,0.00003609054,0.00138536,0.00002752345,0.004692822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001793634,"threshold_uncertainty_score":0.00600028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009022672279460913,"score_gpt":0.2155052244248679,"score_spread":0.206482552145407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}