{"id":"W4310710432","doi":"10.1038/s41541-022-00577-8","title":"mRNA-LNP expressing PfCSP and Pfs25 vaccine candidates targeting infection and transmission of Plasmodium falciparum","year":2022,"lang":"en","type":"article","venue":"npj Vaccines","topic":"Malaria Research and Control","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"U.S. Department of Health and Human Services; National Institutes of Health; Bloomberg Philanthropies; National Institute of Allergy and Infectious Diseases; Johns Hopkins University; George Washington University","keywords":"Malaria; Plasmodium falciparum; Virology; Immunogenicity; Vaccination; Malaria vaccine; Immunity; Immune system; Transmission (telecommunications); Immunology; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000373699,0.0001412157,0.0003334193,0.0001872313,0.0002780244,0.00002569279,0.00005097934,0.00004299529,0.0005866735],"category_scores_gemma":[0.0001221659,0.0001159893,0.0000455156,0.0001763394,0.00001343407,0.0001179072,0.0001010907,0.000256675,9.240958e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002648935,"about_ca_system_score_gemma":0.00006430567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003978926,"about_ca_topic_score_gemma":0.00001986942,"domain_scores_codex":[0.998838,0.00009573837,0.0002801428,0.0002575773,0.0002619442,0.0002665812],"domain_scores_gemma":[0.999427,0.0001027655,0.00009416119,0.0001320009,0.00007496206,0.0001690888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003474892,0.0002486725,0.4193017,0.0007725358,0.0001468556,0.00004811137,0.0008283199,0.0001135678,0.518069,0.0001052878,0.007495639,0.04939541],"study_design_scores_gemma":[0.0256959,0.00444608,0.7065894,0.0005147485,0.0005053686,0.0005163631,0.001222052,0.04256666,0.1371091,0.0008130442,0.0792689,0.0007523639],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920448,0.003502394,0.0002544483,0.00304079,0.00008205164,0.0003794391,0.00001308152,0.00004677211,0.0006361906],"genre_scores_gemma":[0.9983829,0.000441061,0.0002770576,0.00009329666,0.0001391679,0.00004772868,0.00003310268,0.00001902946,0.0005666388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3809599,"threshold_uncertainty_score":0.6423663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01072498854679152,"score_gpt":0.2668721828337143,"score_spread":0.2561471942869228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}