{"id":"W4310710432","doi":"10.1038/s41541-022-00577-8","title":"mRNA-LNP expressing PfCSP and Pfs25 vaccine candidates targeting infection and transmission of Plasmodium falciparum","year":2022,"lang":"en","type":"article","venue":"npj Vaccines","topic":"Malaria Research and Control","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"U.S. Department of Health and Human Services; National Institutes of Health; Bloomberg Philanthropies; National Institute of Allergy and Infectious Diseases; Johns Hopkins University; George Washington University","keywords":"Malaria; Plasmodium falciparum; Virology; Immunogenicity; Vaccination; Malaria vaccine; Immunity; Immune system; Transmission (telecommunications); Immunology; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001428692,0.0004175428,0.0002452537,0.0001663806,0.00008446584,0.0001508719,0.0001962496,0.0002987441,0.0007284314],"category_scores_gemma":[0.0001532609,0.000105206,0.0002028792,0.0001202158,0.0001719022,0.0001695499,0.0001224082,0.0004868653,0.0001897056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000320334,"about_ca_system_score_gemma":0.0002504617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006884555,"about_ca_topic_score_gemma":0.0008022441,"domain_scores_codex":[0.9998755,0.00001606146,0.000007909563,0.000023339,0.00004139357,0.00003586722],"domain_scores_gemma":[0.9999567,0.000006587018,0.00001258414,0.000003112134,0.000008715443,0.00001217793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001258665,0.00006695815,0.00008999151,0.00006262201,0.00000479129,0.00004358018,0.00000899846,0.0003997506,0.9960318,0.00008604002,0.00009943802,0.002980192],"study_design_scores_gemma":[0.0000644617,0.004991495,0.002058318,0.00001590988,0.00005454851,0.0003865274,0.00002697217,0.003276262,0.983536,0.00007468465,0.005504725,0.00001011387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883066,0.002213815,0.00727703,0.0001434487,0.00008770526,0.0001318812,0.0002856657,0.00009080295,0.001463202],"genre_scores_gemma":[0.9881122,0.001848574,0.006841763,0.00008416587,0.00003600645,0.0001274375,0.0007815465,0.00001288917,0.002155452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007284314,"threshold_uncertainty_score":0.002436817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01072498854679152,"score_gpt":0.2668721828337143,"score_spread":0.2561471942869228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}