{"id":"W4310718622","doi":"10.1021/jacs.2c10448","title":"Nickel-Catalyzed Homologation of Vinylidene Difluoride (CH<sub>2</sub>═CF<sub>2</sub>): Selective β-F <i>vs</i> β-H Elimination","year":2022,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; Canada Research Chairs; Arkema; Government of Ontario","keywords":"Chemistry; Difluoride; Catalysis; Reductive elimination; Phosphine; Fluorocarbon; Nickel; Intramolecular force; Fluoride; Xenon difluoride; Medicinal chemistry; Polymer chemistry; Organic chemistry; Inorganic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000608493,0.0002136507,0.0001177768,0.00007041034,0.0001121113,0.0001244957,0.0002531583,0.0001447715,0.001851955],"category_scores_gemma":[0.00011858,0.0000560646,0.0000981269,0.00006095349,0.0001273234,0.0001821923,0.0001937277,0.0002192549,0.0003215671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002065091,"about_ca_system_score_gemma":0.0001534749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001095048,"about_ca_topic_score_gemma":0.002409989,"domain_scores_codex":[0.9999497,0.00000411037,0.000002126894,0.00001094573,0.000008502156,0.0000246351],"domain_scores_gemma":[0.9999835,0.00000247566,0.00000485788,0.000002216126,0.000003410203,0.000003426215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004048986,0.00005981278,0.000785698,0.0003498412,0.00002901626,0.0002756795,0.0001965704,0.0005202796,0.9784887,0.002607546,0.0008047257,0.01547729],"study_design_scores_gemma":[0.00001321206,0.0002843046,0.0007586772,0.00001056244,0.000008544145,0.0001715553,0.00005120902,0.0005298287,0.9923846,0.0001124369,0.005669766,0.000005373724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853005,0.0008150953,0.002748301,0.00007374028,0.00003523766,0.00003225874,0.0002274092,0.00009097706,0.0106765],"genre_scores_gemma":[0.9969506,0.0003629141,0.0006286353,0.00001804882,0.000003332092,0.000007253324,0.0001476478,0.0000129959,0.001868551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001851955,"threshold_uncertainty_score":0.006195366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02087891443758636,"score_gpt":0.3197184484693114,"score_spread":0.298839534031725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}