{"id":"W4310722509","doi":"10.1016/j.jagp.2022.11.013","title":"Intravenous Ketamine for Late-Life Treatment-Resistant Depression: A Pilot Study of Tolerability, Safety, Clinical Benefits, and Effect on Cognition","year":2022,"lang":"en","type":"article","venue":"American Journal of Geriatric Psychiatry","topic":"Treatment of Major Depression","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto; University Health Network","funders":"National Center for Complementary and Integrative Health; National Institute of Mental Health","keywords":"Tolerability; Discontinuation; Adverse effect; Medicine; Ketamine; Treatment-resistant depression; Clinical trial; Cognition; Anesthesia; Major depressive disorder; Psychiatry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009274923,0.0006704447,0.001186135,0.0002160271,0.0002399844,0.0004026527,0.0004703985,0.000478763,0.001121358],"category_scores_gemma":[0.001253028,0.0002557508,0.0005182534,0.000219823,0.0005649665,0.0005585723,0.0001989798,0.001366318,0.0002264907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003763147,"about_ca_system_score_gemma":0.0005591665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006958091,"about_ca_topic_score_gemma":0.001607406,"domain_scores_codex":[0.9996118,0.0001967332,0.00002753742,0.00004647491,0.00004600659,0.00007155145],"domain_scores_gemma":[0.9992889,0.0001676364,0.0001713642,0.00006888681,0.00004280588,0.0002603125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6475474,0.0942804,0.01931349,0.0004806395,0.0009045037,0.0004412731,0.0005146926,0.001040643,0.07846614,0.0002046364,0.0008840836,0.1559221],"study_design_scores_gemma":[0.1111683,0.8330749,0.04876776,0.00002717914,0.0004184884,0.0004077759,0.0001369951,0.001444772,0.003988823,0.0000839033,0.0004510176,0.00003015172],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990242,0.000300169,0.0001699838,0.00003211573,0.00001135385,0.0001843672,0.00005822167,0.00001002165,0.0002097253],"genre_scores_gemma":[0.9986112,0.0004170481,0.000418805,0.00006660512,0.00003944778,0.0001448783,0.0001036507,0.000004924245,0.0001934016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001186135,"threshold_uncertainty_score":0.004905105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02592283319233759,"score_gpt":0.3178400113705069,"score_spread":0.2919171781781694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}