{"id":"W4310725957","doi":"10.1016/j.cllc.2022.11.009","title":"27-gene Immuno-Oncology (IO) Score is Associated With Efficacy of Checkpoint Immunotherapy in Advanced NSCLC: A Retrospective BC Cancer Study","year":2022,"lang":"en","type":"article","venue":"Clinical Lung Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Lung cancer; Internal medicine; Oncology; Cancer; Pembrolizumab; Cohort; Immunotherapy; Nivolumab; Retrospective cohort study; Progression-free survival; PD-L1; Overall survival","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009727423,0.0002419738,0.0003429478,0.0007064093,0.0004183458,0.0006563594,0.0003392434,0.0003746779,0.001062897],"category_scores_gemma":[0.001515592,0.0002835206,0.000531906,0.0008800115,0.0003296838,0.0002847989,0.0003590714,0.0004972855,0.0002904581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004055804,"about_ca_system_score_gemma":0.0003314571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004999331,"about_ca_topic_score_gemma":0.005164212,"domain_scores_codex":[0.9994358,0.0001218753,0.00005655958,0.0001906504,0.0001212488,0.00007377828],"domain_scores_gemma":[0.9985794,0.0002495447,0.0004987923,0.0002062963,0.000217857,0.0002481121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000284476,0.00001526214,0.9988087,0.000004912966,0.00006604977,0.00002536402,0.00001619573,0.00002887466,0.0002202413,0.000006301566,0.00005181148,0.000471716],"study_design_scores_gemma":[0.00001892672,0.0001663816,0.9987254,0.00000393178,0.00009319784,0.0002996348,0.00005523206,0.0002246069,0.0001175324,0.00001475401,0.0002768776,0.000003491076],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986688,0.0003538206,0.00009419178,0.00001391359,0.000004012527,0.00001274858,0.0004704586,0.000002817601,0.0003792249],"genre_scores_gemma":[0.9992067,0.00008571406,0.0000459918,0.0000146698,0.000005969229,0.000009241656,0.0005264472,0.000002206175,0.0001029805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004999331,"threshold_uncertainty_score":0.009940505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03495201550638214,"score_gpt":0.4031342660278066,"score_spread":0.3681822505214244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}