{"id":"W4310725957","doi":"10.1016/j.cllc.2022.11.009","title":"27-gene Immuno-Oncology (IO) Score is Associated With Efficacy of Checkpoint Immunotherapy in Advanced NSCLC: A Retrospective BC Cancer Study","year":2022,"lang":"en","type":"article","venue":"Clinical Lung Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Lung cancer; Internal medicine; Oncology; Cancer; Pembrolizumab; Cohort; Immunotherapy; Nivolumab; Retrospective cohort study; Progression-free survival; PD-L1; Overall survival","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001699545,0.0003760485,0.001543203,0.0002013082,0.0001694189,0.00001217926,0.0003702758,0.0002064688,0.003402489],"category_scores_gemma":[0.0002028669,0.0003152664,0.0004383667,0.001284749,0.0003839935,0.00008399561,0.0001522773,0.00108314,0.000001814177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003314294,"about_ca_system_score_gemma":0.001773344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002643247,"about_ca_topic_score_gemma":0.002006151,"domain_scores_codex":[0.9958085,0.0005256772,0.001535021,0.0008643641,0.0007093321,0.0005571066],"domain_scores_gemma":[0.99752,0.0004264106,0.0008956856,0.0007306484,0.0003059955,0.0001213007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05906314,0.005585873,0.8755891,0.00003670019,0.003244885,0.0001192764,0.003973158,0.0001190268,0.01270403,0.000004114395,0.001556873,0.03800379],"study_design_scores_gemma":[0.04769229,0.009270397,0.9346491,0.0004680732,0.0003855529,0.00001101314,0.001285483,0.0001119073,0.001571898,0.00001410869,0.00413254,0.0004076246],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805698,0.01263502,0.000006384944,0.001782716,0.001358596,0.002814665,0.0001805926,0.00006657832,0.0005856507],"genre_scores_gemma":[0.9920201,0.003025562,0.0000646849,0.002022398,0.0001835753,0.001148091,0.00003572987,0.00009068842,0.001409185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05905998,"threshold_uncertainty_score":0.99993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03495201550638214,"score_gpt":0.4031342660278066,"score_spread":0.3681822505214244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}