{"id":"W4310753897","doi":"10.1016/j.annonc.2022.10.500","title":"398TiP MARIPOSA-2: Randomized phase III study of amivantamab + lazertinib + chemotherapy vs chemotherapy alone in EGFR-mutant NSCLC after osimertinib failure","year":2022,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Osimertinib; Medicine; Chemotherapy; Oncology; Internal medicine; Phases of clinical research; Epidermal growth factor receptor; Cancer; Erlotinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001083956,0.001999983,0.003035076,0.0004599383,0.0004245433,0.001505076,0.001058436,0.001378411,0.009208765],"category_scores_gemma":[0.000871467,0.0007899194,0.002304072,0.0003787809,0.001060654,0.001264742,0.0004792424,0.004382129,0.001801558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001033596,"about_ca_system_score_gemma":0.00127836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001364709,"about_ca_topic_score_gemma":0.003770742,"domain_scores_codex":[0.9996283,0.0001450911,0.00001779268,0.00007861099,0.00002613696,0.000104097],"domain_scores_gemma":[0.9995558,0.00008343106,0.00007379783,0.00003786522,0.00001957008,0.0002296281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9527688,0.008218152,0.0007951252,0.0004392619,0.0010793,0.00004399702,0.00004225579,0.0007673052,0.004170635,0.0002126824,0.001680589,0.02978194],"study_design_scores_gemma":[0.8951322,0.09926756,0.002174068,0.00004074254,0.0006224907,0.00004373372,0.00003055308,0.0007473903,0.0006110211,0.0002625217,0.001042475,0.00002519621],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876709,0.003752005,0.0004687782,0.0008507302,0.0008415409,0.001766177,0.001140024,0.0001749839,0.003335018],"genre_scores_gemma":[0.982626,0.002956803,0.001183537,0.001404023,0.0005349566,0.002360401,0.001740974,0.00006107695,0.00713235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009208765,"threshold_uncertainty_score":0.03080642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02602173890808037,"score_gpt":0.3946457078920597,"score_spread":0.3686239689839794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}