{"id":"W4310777417","doi":"10.1177/10915818221138781","title":"Nonclinical Safety Assessment of Lipid Nanoparticle-and Emulsion-Based Self-Amplifying mRNA Vaccines in Rats","year":2022,"lang":"en","type":"article","venue":"International Journal of Toxicology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"GlaxoSmithKline Biologicals","keywords":"RNA; Immune system; Innate immune system; Vaccination; Messenger RNA; Interferon; Antigen; Biology; Nucleic acid; Immunology; Medicine; Virology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000942801,0.0010138,0.0006540197,0.0006495112,0.0002789518,0.0003975203,0.0004203257,0.0006879511,0.001631482],"category_scores_gemma":[0.0006871606,0.0002835996,0.0005163584,0.0002485366,0.0006422208,0.0006394129,0.0002486968,0.0009746834,0.0006570184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003987696,"about_ca_system_score_gemma":0.0007001658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005850677,"about_ca_topic_score_gemma":0.0008893971,"domain_scores_codex":[0.9994786,0.0001308263,0.00003224263,0.000142901,0.0001132994,0.0001020925],"domain_scores_gemma":[0.9991043,0.0001203858,0.0002906714,0.000139695,0.0002196211,0.0001251943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005420562,0.003070067,0.0009961443,0.0001146264,0.00003688016,0.0001371319,0.0001318157,0.0004820961,0.9781246,0.0001872102,0.0001467145,0.0111522],"study_design_scores_gemma":[0.0003218568,0.098356,0.002679093,0.00002296254,0.0001233999,0.0002498525,0.0001480381,0.001757451,0.8942579,0.0001432375,0.001907943,0.00003222098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907736,0.0005118905,0.006678584,0.0001048455,0.00006786219,0.0003807564,0.0003880911,0.0001808418,0.000913395],"genre_scores_gemma":[0.9816959,0.001406053,0.008148081,0.0001577298,0.00006085171,0.0009551374,0.000741251,0.00006880833,0.006766285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001631482,"threshold_uncertainty_score":0.005457819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01546890436869608,"score_gpt":0.3303352903246742,"score_spread":0.3148663859559781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}