{"id":"W4310777417","doi":"10.1177/10915818221138781","title":"Nonclinical Safety Assessment of Lipid Nanoparticle-and Emulsion-Based Self-Amplifying mRNA Vaccines in Rats","year":2022,"lang":"en","type":"article","venue":"International Journal of Toxicology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"GlaxoSmithKline Biologicals","keywords":"RNA; Immune system; Innate immune system; Vaccination; Messenger RNA; Interferon; Antigen; Biology; Nucleic acid; Immunology; Medicine; Virology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004244802,0.00008005029,0.0001948981,0.0001413434,0.00003559875,0.000009134819,0.0003300493,0.00006107146,0.0001077847],"category_scores_gemma":[0.0001255262,0.00007546489,0.00009579839,0.00005117287,0.00003052612,0.000007084518,0.0002116924,0.0001877422,4.909272e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006228591,"about_ca_system_score_gemma":0.0001866454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006482756,"about_ca_topic_score_gemma":0.00001890745,"domain_scores_codex":[0.9987838,0.0001632278,0.0005791137,0.0001408922,0.0002195335,0.0001134343],"domain_scores_gemma":[0.9991862,0.0001176693,0.0003434466,0.00008898374,0.0002165917,0.00004714611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006960406,0.000500388,0.1580818,0.000007913814,0.0001551452,0.00006312392,0.00005614752,0.003895927,0.8335482,0.00008671299,0.0003882918,0.002520318],"study_design_scores_gemma":[0.009518881,0.008549515,0.3637429,0.000109884,0.00009087208,0.0009615523,0.0005301721,0.008527071,0.5845094,0.0005606006,0.02242837,0.0004707464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966889,0.0002007686,0.0005137007,0.001510533,0.0009115713,0.00005927328,0.00001053212,0.000001783608,0.0001029556],"genre_scores_gemma":[0.997451,0.0001538229,0.001400418,0.0007362722,0.0002094033,0.000006418224,0.000008176714,0.000006805667,0.0000276552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2490388,"threshold_uncertainty_score":0.3077369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01546890436869608,"score_gpt":0.3303352903246742,"score_spread":0.3148663859559781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}