{"id":"W4310782456","doi":"10.1038/s41467-022-35173-w","title":"Single-molecule characterization of subtype-specific β1 integrin mechanics","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"NHLBI Division of Intramural Research; Center for Information Technology; National Research Foundation; National Heart, Lung, and Blood Institute; National Research Foundation of Korea; National Institutes of Health; National Science Foundation; U.S. Department of Health and Human Services; Howard Hughes Medical Institute","keywords":"Integrin; Mechanotransduction; Cytoskeleton; Actin; Cell biology; Focal adhesion; Mechanosensitive channels; Biophysics; Myosin; Chemistry; Stress fiber; Cell adhesion molecule; Actin cytoskeleton; Biology; Cell; Biochemistry; Signal transduction; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001297882,0.00009161091,0.00009506528,0.00007579558,0.0002537814,0.00001407576,0.0007207952,0.0001241092,0.0001335979],"category_scores_gemma":[0.00004768658,0.0001045892,0.00009290099,0.0002300068,0.00002366002,0.000005035584,0.0006862575,0.0005095449,0.000004501215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000380299,"about_ca_system_score_gemma":0.00004668353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004574733,"about_ca_topic_score_gemma":0.00003356973,"domain_scores_codex":[0.9992466,0.0001310188,0.0002093031,0.0001764355,0.0001304778,0.0001061642],"domain_scores_gemma":[0.9983903,0.00001593055,0.000158872,0.001246084,0.0001563564,0.00003242868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001888229,0.0002222685,0.00001648589,0.000002135683,0.00002237104,2.155171e-7,0.00005099847,0.000006521228,0.977755,0.02023459,0.0009614376,0.000709086],"study_design_scores_gemma":[0.0001327779,0.0001512462,0.0000857725,0.000003865848,0.00001107217,0.00001269376,0.0001478042,0.0005821791,0.3636124,0.0001203431,0.6350327,0.0001072436],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9389926,0.01094005,0.03147827,0.004393112,0.002075056,0.0009426422,0.0007735281,0.00008779699,0.010317],"genre_scores_gemma":[0.9950956,0.0007003966,0.0008597729,0.000264379,0.00004373477,0.0000569133,0.002620148,0.00002218584,0.0003369466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6340712,"threshold_uncertainty_score":0.4265023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01747012861900533,"score_gpt":0.2548968532201455,"score_spread":0.2374267246011402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}