{"id":"W4310782456","doi":"10.1038/s41467-022-35173-w","title":"Single-molecule characterization of subtype-specific β1 integrin mechanics","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"NHLBI Division of Intramural Research; Center for Information Technology; National Research Foundation; National Heart, Lung, and Blood Institute; National Research Foundation of Korea; National Institutes of Health; National Science Foundation; U.S. Department of Health and Human Services; Howard Hughes Medical Institute","keywords":"Integrin; Mechanotransduction; Cytoskeleton; Actin; Cell biology; Focal adhesion; Mechanosensitive channels; Biophysics; Myosin; Chemistry; Stress fiber; Cell adhesion molecule; Actin cytoskeleton; Biology; Cell; Biochemistry; Signal transduction; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009897683,0.0001316205,0.0001642094,0.0002265657,0.0001644335,0.0002789276,0.0002277057,0.0002812411,0.001225972],"category_scores_gemma":[0.0002002472,0.0001153234,0.0001131507,0.0001575035,0.0001019919,0.0001937535,0.00007091092,0.0002452378,0.0004142273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001870765,"about_ca_system_score_gemma":0.00008100201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001043865,"about_ca_topic_score_gemma":0.001885404,"domain_scores_codex":[0.9999304,0.000003730966,0.000003725917,0.00002051605,0.00002502977,0.00001662315],"domain_scores_gemma":[0.9998786,0.00002719552,0.00003093892,0.00001429756,0.00002446891,0.00002442878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000112718,0.000005752764,0.0006257404,0.000008164241,0.000001603439,0.00001165233,0.000008575984,0.00004174074,0.9984726,0.00003628284,0.00002760521,0.0007489672],"study_design_scores_gemma":[0.000007500603,0.0001291828,0.07975029,0.000006421114,0.00001795044,0.0002993092,0.0001097572,0.008668043,0.9087377,0.0001190337,0.002141378,0.00001334992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928365,0.0004165659,0.004692968,0.00003188591,0.00001143218,0.00001592113,0.0004531653,0.00004629918,0.001495207],"genre_scores_gemma":[0.9936097,0.0003842816,0.003744554,0.0000399472,0.00001010035,0.00004570553,0.000559766,0.00001731076,0.001588685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001225972,"threshold_uncertainty_score":0.004101276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01747012861900533,"score_gpt":0.2548968532201455,"score_spread":0.2374267246011402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}