{"id":"W4310786884","doi":"10.1016/j.eclinm.2022.101737","title":"Effects of once-weekly semaglutide 2.4 mg on C-reactive protein in adults with overweight or obesity (STEP 1, 2, and 3): exploratory analyses of three randomised, double-blind, placebo-controlled, phase 3 trials","year":2022,"lang":"en","type":"article","venue":"EClinicalMedicine","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Novo Nordisk","keywords":"Medicine; Semaglutide; Overweight; Placebo; Physical therapy; Obesity; Double blind; Gerontology; Internal medicine; Alternative medicine; Type 2 diabetes; Endocrinology; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003915941,0.001552822,0.004239801,0.0005201624,0.0003976843,0.001500934,0.0008594884,0.001774761,0.003389484],"category_scores_gemma":[0.00361883,0.0006403536,0.005574337,0.0005590796,0.0009717539,0.00134367,0.0005162467,0.002744368,0.0005241093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008144283,"about_ca_system_score_gemma":0.001018075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001139196,"about_ca_topic_score_gemma":0.003447962,"domain_scores_codex":[0.9986989,0.0007110471,0.0001315675,0.0001873486,0.0001265511,0.0001445146],"domain_scores_gemma":[0.997921,0.000765076,0.0006511529,0.000139916,0.0001408132,0.0003819378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9549494,0.002916824,0.00135545,0.002352367,0.007264601,0.00005958443,0.0001021516,0.0004898878,0.002593595,0.00007778816,0.0007855565,0.02705277],"study_design_scores_gemma":[0.896486,0.0856374,0.009569103,0.000302663,0.005810902,0.00008442573,0.00005403685,0.0005227161,0.0006303158,0.0002991403,0.0005619572,0.00004131599],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706236,0.02355164,0.0005469384,0.0007441041,0.0003147754,0.001728547,0.0009964971,0.0001535425,0.001340501],"genre_scores_gemma":[0.9859858,0.007496699,0.001580259,0.001035555,0.0002210166,0.001914575,0.0007484434,0.00002887345,0.0009888666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004239801,"threshold_uncertainty_score":0.02070969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06822644034493452,"score_gpt":0.3738609045850374,"score_spread":0.3056344642401029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}