{"id":"W4310871018","doi":"10.14309/01.ajg.0000897656.25080.34","title":"S37 Efficacy and Safety of Upadacitinib Maintenance Therapy in Patients With Moderately to Severely Active Crohn’s Disease: U-ENDURE Phase 3 Results","year":2022,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Internal medicine; Gastroenterology; Crohn's disease; Maintenance therapy; Placebo; Disease; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002140658,0.0004589772,0.001495435,0.0002296056,0.0003191223,0.0008439171,0.0004178156,0.00074002,0.005776666],"category_scores_gemma":[0.001758278,0.0001968118,0.002133682,0.0003195922,0.0003575859,0.000607706,0.0003987738,0.001423282,0.0008522772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005087536,"about_ca_system_score_gemma":0.0007854758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005023401,"about_ca_topic_score_gemma":0.002224834,"domain_scores_codex":[0.9994037,0.0002915163,0.00007185594,0.00005263845,0.0000885365,0.00009178847],"domain_scores_gemma":[0.9988495,0.0002884528,0.0003531014,0.00008117714,0.0001606976,0.0002670613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5485688,0.007853913,0.02195518,0.003744019,0.00486176,0.0003089879,0.0002657058,0.002040696,0.03243358,0.0004651932,0.01277576,0.3647265],"study_design_scores_gemma":[0.3028519,0.4449055,0.1735099,0.001168226,0.009454506,0.001706269,0.0002981787,0.004464023,0.02435429,0.0007852209,0.03634609,0.0001559776],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9624929,0.02335813,0.0009420757,0.001272707,0.000199832,0.001526059,0.00473294,0.000136701,0.005338479],"genre_scores_gemma":[0.9876348,0.003887634,0.001308011,0.0009309202,0.0001370468,0.0006146377,0.003886868,0.00002023404,0.001579928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005776666,"threshold_uncertainty_score":0.0193249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005589723619297231,"score_gpt":0.2347986272855711,"score_spread":0.2292089036662739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}