{"id":"W4310871604","doi":"10.14309/01.ajg.0000897628.50103.7d","title":"S30 A Phase 2b Study to Evaluate the Efficacy and Safety of Investigational Microbiome Therapeutic SER-287 in Mildly-to-Moderately Active UC","year":2022,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"","keywords":"Medicine; Internal medicine; Ulcerative colitis; Placebo; Gastroenterology; Inflammatory bowel disease; Concomitant; Phases of clinical research; Clinical trial; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001237376,0.001060283,0.001471042,0.0003188483,0.000315664,0.0005769292,0.0006749198,0.001258418,0.007826753],"category_scores_gemma":[0.0007307092,0.0004139791,0.0009301924,0.0002157461,0.0006391631,0.0004955213,0.000270935,0.002163138,0.001410544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004395854,"about_ca_system_score_gemma":0.001251605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005130913,"about_ca_topic_score_gemma":0.001159801,"domain_scores_codex":[0.999723,0.0001365645,0.00001361344,0.00004814817,0.00002956799,0.00004911064],"domain_scores_gemma":[0.9994603,0.00008804245,0.00008839825,0.00004589585,0.00006079116,0.0002566171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.805757,0.07252887,0.003116646,0.001308888,0.00085926,0.0002408472,0.000145892,0.00115699,0.04967609,0.0004048054,0.005478292,0.05932644],"study_design_scores_gemma":[0.5733159,0.4156153,0.004796048,0.00004215771,0.0002566612,0.0001832493,0.0000328594,0.0008351571,0.002734055,0.000209736,0.001962389,0.00001658282],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865586,0.002125577,0.0009441043,0.000535453,0.0001720436,0.005247783,0.001991965,0.0001680994,0.002256426],"genre_scores_gemma":[0.9834593,0.001578208,0.002615036,0.00119218,0.0001436696,0.004615094,0.002785252,0.00003306179,0.00357826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007826753,"threshold_uncertainty_score":0.02618307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01741032149466668,"score_gpt":0.3192933183087023,"score_spread":0.3018829968140356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}