{"id":"W4310881240","doi":"10.1371/journal.pgen.1010309","title":"RAD18 opposes transcription-associated genome instability through FANCD2 recruitment","year":2022,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Terry Fox Research Institute","funders":"Institute of Genetics; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Biology; DNA re-replication; Genome instability; Pre-replication complex; DNA replication; DNA replication factor CDT1; Control of chromosome duplication; Genetics; Origin recognition complex; Eukaryotic DNA replication; Transcription (linguistics); Minichromosome maintenance; DNA repair; Cell biology; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001374496,0.0003302755,0.0002158535,0.0001824009,0.0001546535,0.0003817074,0.0002850137,0.0002238977,0.00273563],"category_scores_gemma":[0.0001076309,0.0001374463,0.0001493545,0.00009205654,0.0002333631,0.0001782371,0.0002857317,0.0003332448,0.0006392536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002710267,"about_ca_system_score_gemma":0.0002019555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002460704,"about_ca_topic_score_gemma":0.000448152,"domain_scores_codex":[0.9998691,0.0000193873,0.00001154137,0.00003956065,0.00002698844,0.00003337841],"domain_scores_gemma":[0.9998589,0.00001897006,0.00004423803,0.00002061244,0.00001637229,0.0000409626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004760891,0.000007324628,0.0001459711,0.00001768689,0.000001510001,0.00003863326,0.000005176305,0.00001873382,0.9991518,0.00008933015,0.00002618669,0.0004498799],"study_design_scores_gemma":[0.000006836891,0.00004032441,0.001624448,0.000002601255,0.000002460572,0.0001354038,0.000008615031,0.0003179028,0.9954809,0.00003317331,0.002345684,0.000001509665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910212,0.001566755,0.004566727,0.0001389478,0.00003483472,0.00001806872,0.0003113422,0.0002401595,0.002101902],"genre_scores_gemma":[0.9942486,0.0003819655,0.002031635,0.00003450571,0.000008912627,0.0000171024,0.0003060177,0.00004507472,0.002926237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00273563,"threshold_uncertainty_score":0.009151638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06402277057991747,"score_gpt":0.2738056738920095,"score_spread":0.209782903312092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}