{"id":"W4310943225","doi":"10.1021/jacs.2c04039","title":"An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4","year":2022,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds De La Recherche Scientifique - FNRS; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; University of California Berkeley; Novartis Institutes for BioMedical Research; Damon Runyon Cancer Research Foundation; National Institute of Environmental Health Sciences; American Cancer Society; National Institutes of Health; National Science Foundation","keywords":"Chemistry; Allosteric regulation; Biochemistry; Methionine; Affinity label; Cysteine; Enzyme; Amino acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001152513,0.0003909052,0.0001672667,0.0001574163,0.000112344,0.0001556233,0.0003035427,0.0002467073,0.001144291],"category_scores_gemma":[0.00009515577,0.0001373685,0.0001688623,0.0001329661,0.0001404078,0.0001836255,0.0002526705,0.0003369452,0.0003756876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002754172,"about_ca_system_score_gemma":0.0001826358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003199714,"about_ca_topic_score_gemma":0.0006875847,"domain_scores_codex":[0.9999301,0.00001090911,0.000004727839,0.00001845327,0.00001642027,0.00001930424],"domain_scores_gemma":[0.9999621,0.000004605781,0.00001529746,0.000004158929,0.000005969675,0.000007936898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008326727,0.00004102533,0.0001622209,0.0001188454,0.000009561823,0.00009863358,0.00002561294,0.0004868003,0.989062,0.0007893528,0.0002025687,0.008920104],"study_design_scores_gemma":[0.00002107403,0.000435186,0.0003593248,0.000005186615,0.00001424354,0.0001737955,0.00001098987,0.0007522955,0.9915148,0.00007084562,0.0066344,0.000007833901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9437465,0.004287852,0.03920645,0.0003886711,0.00008098012,0.0001734263,0.0005773755,0.0005632624,0.01097554],"genre_scores_gemma":[0.9816844,0.001965978,0.01150936,0.0001266989,0.0000149906,0.00006552799,0.0003000824,0.00002166893,0.004311346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001144291,"threshold_uncertainty_score":0.003828049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05013740361543237,"score_gpt":0.3172874471006252,"score_spread":0.2671500434851929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}