{"id":"W4310944664","doi":"10.1038/s41380-022-01867-2","title":"Genetic risk for attention-deficit/hyperactivity disorder predicts cognitive decline and development of Alzheimer’s disease pathophysiology in cognitively unimpaired older adults","year":2022,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ministério da Ciência, Tecnologia e Inovação; Brain and Behavior Research Foundation","keywords":"Psychology; Cognition; Cognitive decline; Attention deficit hyperactivity disorder; Pittsburgh compound B; Disease; Dementia; Psychiatry; Clinical psychology; Medicine; Internal medicine; Cognitive impairment","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003876466,0.0005998639,0.0003849616,0.001025948,0.0006250407,0.0008000618,0.0005558297,0.0009783547,0.002774134],"category_scores_gemma":[0.002450608,0.0003492717,0.0006040927,0.000823197,0.0004588141,0.0006238608,0.0005438806,0.0008686759,0.0003065846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003209962,"about_ca_system_score_gemma":0.000328745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01400251,"about_ca_topic_score_gemma":0.01322195,"domain_scores_codex":[0.9997603,0.00005078215,0.00003248186,0.00006773249,0.00004099425,0.00004758033],"domain_scores_gemma":[0.9989504,0.000173584,0.0004641177,0.00007225376,0.0001155613,0.0002242318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001613962,0.00007772498,0.9979287,0.000007707096,0.00008841283,0.000257452,0.00007500967,0.00003168307,0.0003141255,0.00003002034,0.00008783353,0.0009399786],"study_design_scores_gemma":[0.000003998856,0.00005482167,0.9992597,0.000004656044,0.00003746455,0.0003129959,0.00009179546,0.00009774129,0.00003316517,0.00005071578,0.00005064705,0.000002320329],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986529,0.000357264,0.00004948067,0.000105292,0.00001727881,0.00000353633,0.0001334361,0.000003533033,0.0006772138],"genre_scores_gemma":[0.9993432,0.000107372,0.00006148266,0.00004081828,0.00002451626,0.000002126467,0.0001202443,0.000001812507,0.0002983976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01400251,"threshold_uncertainty_score":0.02784199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412854567884206,"score_gpt":0.2824970890164675,"score_spread":0.2683685433376254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}