{"id":"W4310946316","doi":"10.1128/mbio.02639-22","title":"A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Candida albicans; Fluconazole; Fungicide; Corpus albicans; Microbiology; Ergosterol; Small molecule; Biology; Chemistry; Antifungal; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006383177,0.0001276493,0.0003128312,0.00003303296,0.0001955855,0.000007626197,0.0002439745,0.00004824267,0.0002547525],"category_scores_gemma":[0.0003874173,0.00007709557,0.0002330737,0.0002707847,0.0002073432,0.00002237791,0.0002315671,0.0002788132,0.000003804666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005496994,"about_ca_system_score_gemma":0.0001010103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001270864,"about_ca_topic_score_gemma":0.00004957156,"domain_scores_codex":[0.9985139,0.0002099597,0.0003997571,0.0002243853,0.0004292117,0.0002228342],"domain_scores_gemma":[0.9989071,0.0003030061,0.0002058653,0.0004605846,0.0000794496,0.00004401089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002885479,0.0002536127,0.05078609,0.000169051,0.00006827805,0.000005528401,0.0006728827,0.000007523181,0.9423851,0.0001488727,0.002997932,0.002216617],"study_design_scores_gemma":[0.0004304715,0.0001711182,0.02213411,0.0001000185,0.0001051597,0.000008346549,0.002629355,0.00007389453,0.9726142,0.00005956736,0.00158094,0.0000928587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941309,0.0007905941,0.00003308307,0.001502586,0.00009454985,0.0003805616,0.000129716,0.00001689451,0.002921124],"genre_scores_gemma":[0.9981297,0.000008102043,0.00005709029,0.0004960365,0.00004536709,0.0000475301,0.00000630505,0.0000176749,0.001192235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0302291,"threshold_uncertainty_score":0.3143866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01530474254217797,"score_gpt":0.2293605220905695,"score_spread":0.2140557795483915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}