{"id":"W4310954682","doi":"10.1172/jci.insight.150368","title":"Biallelic TET2 mutations confer sensitivity to 5′-azacitidine in acute myeloid leukemia","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Associazione Italiana per la Ricerca sul Cancro; Technische Universität Dresden; Fundación Científica Asociación Española Contra el Cáncer; Newcastle University; Cancer Research UK; Blood Cancer UK; JGW Patterson Foundation; DNA Genotek; University of California, San Francisco; Memorial Sloan-Kettering Cancer Center","keywords":"Azacitidine; Myeloid leukemia; Cancer research; Cytarabine; Hypomethylating agent; Decitabine; Medicine; Myeloid; Mutation; Allele; Anthracycline; Leukemia; Mutant; Cancer; Biology; Oncology; Internal medicine; Gene; Genetics; DNA methylation; Breast cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001135249,0.0001511815,0.0001844696,0.0001674146,0.0001687945,0.0002828359,0.00007764783,0.0002874408,0.0009725425],"category_scores_gemma":[0.000193918,0.00006765092,0.0001071067,0.0001401496,0.000175429,0.0001075049,0.0001441632,0.0003308383,0.0002078571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000204239,"about_ca_system_score_gemma":0.0001054422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006865152,"about_ca_topic_score_gemma":0.001006182,"domain_scores_codex":[0.9999273,0.00001314075,0.000009720482,0.00001743379,0.00001810419,0.00001424566],"domain_scores_gemma":[0.9999284,0.00001898304,0.00002017535,0.000007115436,0.000006859731,0.00001848422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005028694,0.00007130463,0.04734061,0.00005882557,0.00002541456,0.008304827,0.0002724192,0.0004428358,0.9224269,0.0005288082,0.0003402125,0.01968489],"study_design_scores_gemma":[0.00004306572,0.001793231,0.3257491,0.0000200415,0.0001511235,0.09731097,0.0005590017,0.00323732,0.5597969,0.0008856305,0.01042901,0.00002457497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970163,0.0006844332,0.000609707,0.000215815,0.00000764768,0.000009190563,0.00009680688,0.00002815063,0.001331958],"genre_scores_gemma":[0.9990112,0.0002527518,0.0002918289,0.00005789369,0.000005294125,0.000002091665,0.00005687396,0.000003935104,0.0003182031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009725425,"threshold_uncertainty_score":0.00325346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02730920916075084,"score_gpt":0.3031356013879044,"score_spread":0.2758263922271535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}