{"id":"W4310959732","doi":"10.1158/0008-5472.can-22-2912","title":"The Cytidine Deaminase APOBEC3G Contributes to Cancer Mutagenesis and Clonal Evolution in Bladder Cancer","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Weill Cornell Medical College; National Institutes of Health; National Institute of Allergy and Infectious Diseases; C.V. Starr Center for the Study of the American Experience, Washington College","keywords":"Cytidine deaminase; Somatic hypermutation; Mutagenesis; Biology; APOBEC3G; Cancer; Somatic evolution in cancer; Genome instability; Genetics; APOBEC; Cancer research; Bladder cancer; Insertional mutagenesis; Mutation; Cancer cell; Genome; Gene; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00103031,0.0003574527,0.0004045438,0.0005210939,0.0007146677,0.001002025,0.0007014551,0.00343806,0.001693157],"category_scores_gemma":[0.001426962,0.0002523342,0.0004002913,0.0004319143,0.002307305,0.001126727,0.0006327303,0.005571956,0.0005162866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001743415,"about_ca_system_score_gemma":0.0009435859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005404152,"about_ca_topic_score_gemma":0.01307673,"domain_scores_codex":[0.9995068,0.0001123849,0.00002500805,0.0001455449,0.0001614149,0.00004874803],"domain_scores_gemma":[0.9990688,0.0005249638,0.00006388041,0.00003707114,0.0002087989,0.0000966006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001344154,0.0001487616,0.009259195,0.002092136,0.0001862542,0.003182785,0.0008212052,0.002420925,0.1934237,0.03174294,0.3748088,0.3805691],"study_design_scores_gemma":[0.0001647313,0.0005012871,0.02260366,0.0006379882,0.0002172064,0.00463808,0.0006689905,0.003906162,0.07826291,0.03852917,0.8496968,0.0001729352],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.06496553,0.3423969,0.01111368,0.5333935,0.03177087,0.00008480265,0.0004489315,0.0004648564,0.01536092],"genre_scores_gemma":[0.3313185,0.3583513,0.006118492,0.20381,0.05833828,0.0000882298,0.0002291818,0.0002003701,0.04154565],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005404152,"threshold_uncertainty_score":0.01264948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03420078390267148,"score_gpt":0.3864930046930629,"score_spread":0.3522922207903914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}