{"id":"W4311002499","doi":"10.3390/pharmaceutics14122656","title":"Stable Cavitation-Mediated Delivery of miR-126 to Endothelial Cells","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Heart and Stroke Foundation of Canada; Burroughs Wellcome Fund","keywords":"Microbubbles; Angiogenesis; Transfection; Umbilical vein; Intracellular; Sonoporation; Chemistry; Gene delivery; Cell biology; Ultrasound; Biomedical engineering; Medicine; Cancer research; Biology; Biochemistry; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004388393,0.0003112463,0.0002490054,0.0001545864,0.0002000066,0.0002891129,0.0002654876,0.0004186177,0.0007473365],"category_scores_gemma":[0.0003556549,0.000180693,0.0002802823,0.0001457052,0.0002912157,0.000204589,0.0001776696,0.000424624,0.0002873243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004999738,"about_ca_system_score_gemma":0.0002598587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006663707,"about_ca_topic_score_gemma":0.000805973,"domain_scores_codex":[0.9997069,0.00005872502,0.00002200484,0.0000915596,0.000085967,0.00003483173],"domain_scores_gemma":[0.9998393,0.00004715578,0.00004760692,0.00001794809,0.00003290561,0.0000150523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002569678,0.000007127562,0.00002230432,0.0000192979,0.000001422198,0.00001103553,0.000007028365,0.00004851344,0.9992244,0.00004028823,0.0000160504,0.0005767196],"study_design_scores_gemma":[0.000003603242,0.00007264571,0.0002609305,0.000001150197,0.000002631532,0.00003947939,0.000002211078,0.0006304113,0.9984159,0.000008710417,0.0005598215,0.000002553846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9281868,0.00248013,0.06581842,0.0001726125,0.00006758358,0.0002039812,0.000281118,0.0003342949,0.002455055],"genre_scores_gemma":[0.9614458,0.0012054,0.03145742,0.00008595786,0.00001760782,0.0002125514,0.0003360374,0.0000470188,0.005192143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007473365,"threshold_uncertainty_score":0.003627598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02215327580377806,"score_gpt":0.2601835427129722,"score_spread":0.2380302669091941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}