{"id":"W4311021757","doi":"10.1038/s41380-022-01897-w","title":"Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium","year":2022,"lang":"en","type":"review","venue":"Molecular Psychiatry","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McGill University; Mental Health Research Canada; Montreal Neurological Institute and Hospital","funders":"European Social Fund; National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; U.S. Department of Health and Human Services; NIHR Sheffield Biomedical Research Centre; National Institute for Health and Care Research; National Research Foundation; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Health and Medical Research Council; Office of Health and Medical Research; Canadian Institutes of Health Research; Maryland Population Research Center, University of Maryland; National Institutes of Health; NIH Clinical Center; Ramsay Health Care; Innovative Medicines Initiative; Centro de Investigación Biomédica en Red de Salud Mental; King's College London; European Regional Development Fund; Australian Schizophrenia Research Bank; National Healthcare Group; Ministero della Salute; Centre of Excellence in Cognition and its Disorders, Australian Research Council; Medical Research Council; Instituto de Salud Carlos III; National Natural Science Foundation of China; National Research Foundation of Korea; Korea Health Industry Development Institute; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministerio de Ciencia e Innovación; European Commission; Ministerstvo Zdravotnictví Ceské Republiky; NSW Ministry of Health; U.S. Department of Energy; National Institute of Neurological Disorders and Stroke; Beijing Municipal Administration of Hospitals; FP7 Health; Macquarie University; Generalitat de Catalunya; Jeonbuk National University; National Institute on Aging; Pratt Foundation; UK Research and Innovation; Korea Brain Research Institute; Sylvia and Charles Viertel Charitable Foundation; Science Foundation Ireland; National Science Foundation; Centre for Addiction and Mental Health Foundation; Fundación Alicia Koplowitz; Horizon 2020 Framework Programme; Universität Basel; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Schizophrenia (object-oriented programming); Ageing; Psychology; Neuroscience; Psychiatry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009858081,0.0008650591,0.001459715,0.0005385483,0.0006085219,0.0002458318,0.002202795,0.0002534423,0.0007073841],"category_scores_gemma":[0.009894687,0.0007280858,0.0008989817,0.001341621,0.0003392286,0.0002871414,0.001339576,0.002211798,0.0002509193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004291766,"about_ca_system_score_gemma":0.0007339641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002232743,"about_ca_topic_score_gemma":0.0003765416,"domain_scores_codex":[0.9927199,0.002036956,0.001132926,0.002062984,0.001426836,0.0006204229],"domain_scores_gemma":[0.9869958,0.01073127,0.0007271735,0.001391268,0.00003498597,0.0001194897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007276508,0.0007808692,0.0006125639,0.003047851,0.00121023,0.003388012,0.0004345147,0.0002994934,0.001265476,0.009789343,0.0328362,0.9456078],"study_design_scores_gemma":[0.000754336,0.00007819938,0.0002804754,0.004394687,0.0003210338,0.000283993,0.00003334644,0.0001046378,0.00005462982,0.004712053,0.9880276,0.0009549509],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001164251,0.9743164,0.0006019135,0.01177,0.009618618,0.00145889,0.0001674136,0.0002411968,0.0006612667],"genre_scores_gemma":[0.002291522,0.9865703,0.0008375431,0.007767153,0.0009142649,0.001085044,0.0000619088,0.0002541423,0.000218151],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9551914,"threshold_uncertainty_score":0.999517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04481917665882412,"score_gpt":0.3111165324806467,"score_spread":0.2662973558218226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}