{"id":"W4311021757","doi":"10.1038/s41380-022-01897-w","title":"Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium","year":2022,"lang":"en","type":"review","venue":"Molecular Psychiatry","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McGill University; Mental Health Research Canada; Montreal Neurological Institute and Hospital","funders":"European Social Fund; National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; U.S. Department of Health and Human Services; NIHR Sheffield Biomedical Research Centre; National Institute for Health and Care Research; National Research Foundation; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Health and Medical Research Council; Office of Health and Medical Research; Canadian Institutes of Health Research; Maryland Population Research Center, University of Maryland; National Institutes of Health; NIH Clinical Center; Ramsay Health Care; Innovative Medicines Initiative; Centro de Investigación Biomédica en Red de Salud Mental; King's College London; European Regional Development Fund; Australian Schizophrenia Research Bank; National Healthcare Group; Ministero della Salute; Centre of Excellence in Cognition and its Disorders, Australian Research Council; Medical Research Council; Instituto de Salud Carlos III; National Natural Science Foundation of China; National Research Foundation of Korea; Korea Health Industry Development Institute; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministerio de Ciencia e Innovación; European Commission; Ministerstvo Zdravotnictví Ceské Republiky; NSW Ministry of Health; U.S. Department of Energy; National Institute of Neurological Disorders and Stroke; Beijing Municipal Administration of Hospitals; FP7 Health; Macquarie University; Generalitat de Catalunya; Jeonbuk National University; National Institute on Aging; Pratt Foundation; UK Research and Innovation; Korea Brain Research Institute; Sylvia and Charles Viertel Charitable Foundation; Science Foundation Ireland; National Science Foundation; Centre for Addiction and Mental Health Foundation; Fundación Alicia Koplowitz; Horizon 2020 Framework Programme; Universität Basel; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Schizophrenia (object-oriented programming); Ageing; Psychology; Neuroscience; Psychiatry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01547224,0.001616664,0.00246777,0.0031108,0.0008323297,0.002203327,0.001404156,0.001230162,0.001803521],"category_scores_gemma":[0.01755411,0.000930402,0.008946926,0.004659423,0.0007916507,0.0006641649,0.002225617,0.0009589216,0.0002004887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005364791,"about_ca_system_score_gemma":0.0007053568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009512871,"about_ca_topic_score_gemma":0.00991926,"domain_scores_codex":[0.9902089,0.005387647,0.001326784,0.002012099,0.0007851171,0.000279495],"domain_scores_gemma":[0.9846237,0.006193134,0.004812995,0.002458227,0.001428358,0.0004835702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009609265,0.00006482052,0.7083614,0.004294889,0.262047,0.0003628316,0.0003458491,0.00106189,0.0006993302,0.0002553722,0.001503465,0.01139397],"study_design_scores_gemma":[0.001625092,0.0006103409,0.767552,0.001284493,0.2232023,0.0004854812,0.0003303248,0.000865286,0.0003681516,0.0005180612,0.003072252,0.00008626805],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8472528,0.139909,0.002912298,0.0006640428,0.0002776988,0.0001616345,0.007703366,0.00005771858,0.001061493],"genre_scores_gemma":[0.9854608,0.00978163,0.0007575447,0.0001919048,0.00008726377,0.0001027606,0.003449753,0.00002555636,0.000142759],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01547224,"threshold_uncertainty_score":0.08182597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04481917665882412,"score_gpt":0.3111165324806467,"score_spread":0.2662973558218226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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