{"id":"W4311024321","doi":"10.1139/bcb-2022-0291","title":"MTHFD2 suppresses glioblastoma progression via the inhibition of ERK1/2 phosphorylation","year":2022,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Gene knockdown; Cancer research; Glioma; Immunohistochemistry; Glioblastoma; Biology; Western blot; Phosphorylation; Kinase; Cell culture; Immunology; Cell biology; Biochemistry; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001335836,0.0003827959,0.0003881645,0.0002061701,0.0002052214,0.0001988112,0.0001572375,0.0002330172,0.001149465],"category_scores_gemma":[0.00008339674,0.00009954551,0.0003253465,0.0001622406,0.0001672145,0.0001624609,0.0001579389,0.0006673027,0.0002166023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002096115,"about_ca_system_score_gemma":0.0003541138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000879421,"about_ca_topic_score_gemma":0.001995042,"domain_scores_codex":[0.9999245,0.00001170089,0.000006053357,0.00001030662,0.00001452871,0.00003279184],"domain_scores_gemma":[0.9999789,0.000002500256,0.000004906672,0.00000234303,0.000003621895,0.000007847721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001640722,0.0006671909,0.0007138846,0.0004577809,0.00005550343,0.0001499792,0.00005510118,0.0003641176,0.9801122,0.0003240948,0.001196851,0.01426252],"study_design_scores_gemma":[0.0004870765,0.003115426,0.01575236,0.00004464831,0.0001336472,0.0006571611,0.0001374908,0.004848022,0.9575077,0.0002997125,0.01699501,0.00002183552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864444,0.007962642,0.001684685,0.0004247966,0.0001596272,0.00005956079,0.0005438223,0.0001635093,0.002556964],"genre_scores_gemma":[0.9925356,0.003306806,0.0009849458,0.0001266726,0.00002389798,0.00007016877,0.0006030605,0.00001260955,0.002336314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001149465,"threshold_uncertainty_score":0.003845394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006504035720058947,"score_gpt":0.2410651072758185,"score_spread":0.2345610715557595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}