{"id":"W4311039790","doi":"10.3390/cells11233828","title":"Extracellular Vesicles from Ocular Melanoma Have Pro-Fibrotic and Pro-Angiogenic Properties on the Tumor Microenvironment","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; University of California, San Diego; Canada Foundation for Innovation; Fondation des Maladies de l'Oeil; Fonds de Recherche du Québec - Santé; Thomas Jefferson University; Fondation CHU de Québec; Université Laval","keywords":"Hepatic stellate cell; Cell biology; Extracellular matrix; Tumor microenvironment; Biology; Flow cytometry; Angiogenesis; Chemistry; Immune system; Pathology; Cancer research; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002441739,0.0002590412,0.0001619166,0.00002958671,0.0003445339,0.0000553918,0.0004114703,0.00005586694,0.0002423048],"category_scores_gemma":[0.0000259716,0.0002023747,0.0001450633,0.00004595462,0.0002230484,0.00000465295,0.0004888571,0.0001785997,0.00005355324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004411261,"about_ca_system_score_gemma":0.00005203928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001627983,"about_ca_topic_score_gemma":0.000002298916,"domain_scores_codex":[0.9982576,0.0002709143,0.0002476167,0.0006042219,0.0002879449,0.0003317057],"domain_scores_gemma":[0.9989747,0.00002338141,0.0001163766,0.0007553295,0.00001419983,0.0001160123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001395635,0.0002083586,0.0009308628,0.00002310601,0.00009374698,0.00006093517,0.0001822433,0.0002117998,0.9961109,0.00005573008,0.001574577,0.0004082428],"study_design_scores_gemma":[0.0003913069,0.0003256934,0.0006764814,0.00001567431,0.00007086441,0.00001751919,0.0005105049,0.0002427383,0.9524971,0.0001445535,0.04482486,0.0002826916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729515,0.02539341,0.00006039041,0.0003714644,0.0001026478,0.000904222,0.00008652954,0.00001732615,0.0001125327],"genre_scores_gemma":[0.9962897,0.00008307874,0.0002775406,0.0004150571,0.0001368374,0.000280812,0.00008920662,0.00006016717,0.002367637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04361372,"threshold_uncertainty_score":0.8252601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01305440500532071,"score_gpt":0.1910489515529513,"score_spread":0.1779945465476306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}