{"id":"W4311039875","doi":"10.3390/cells11233834","title":"Delivery of Active AKT1 to Human Cells","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"AKT1; Phosphorylation; Cell biology; Transfection; Biology; Kinase; Protein kinase B; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001017223,0.0000985205,0.000115131,0.00003933645,0.0000908045,0.00000532065,0.0002741704,0.0000494025,0.0004607441],"category_scores_gemma":[0.000004842335,0.0001128737,0.00007956038,0.00008993443,0.00003684279,0.000001298275,0.0002831268,0.00008962469,0.00002361084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004120071,"about_ca_system_score_gemma":0.00006629603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004608512,"about_ca_topic_score_gemma":0.000006973895,"domain_scores_codex":[0.9992133,0.00005262578,0.0001404488,0.0002682754,0.0001493235,0.0001759926],"domain_scores_gemma":[0.9994833,0.0000102937,0.0000717244,0.0003172389,0.00005393011,0.00006351869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005672803,0.00005220838,0.00004416357,0.000009582902,0.0000309052,0.000003008859,0.0001270924,0.001224912,0.9774743,0.00001139531,0.02015434,0.0008113485],"study_design_scores_gemma":[0.0001911214,0.0003647137,0.00008284027,0.000003470383,0.00001062031,0.000001092687,0.000114429,0.000004722561,0.8848574,0.00002091778,0.1142303,0.0001184102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99584,0.0002189855,0.0001088457,0.00002917534,0.0003962616,0.000149707,0.0001193121,0.000007794541,0.003129964],"genre_scores_gemma":[0.9963159,0.00001309565,0.000268871,0.0004435723,0.0001442326,0.00003401078,0.00003997295,0.00002196827,0.002718369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09407595,"threshold_uncertainty_score":0.5044824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01014190276917181,"score_gpt":0.2485863312061706,"score_spread":0.2384444284369988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}