{"id":"W4311049970","doi":"10.3390/cancers14235944","title":"A Signaling Crosstalk Links SNAIL to the 37/67 kDa Laminin-1 Receptor Ribosomal Protein SA and Regulates the Acquisition of a Cancer Stem Cell Molecular Signature in U87 Glioblastoma Neurospheres","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"SOX2; Biology; Neurosphere; Cancer research; SNAI1; Cancer stem cell; Gene signature; Stem cell; Homeobox protein NANOG; Epithelial–mesenchymal transition; LGR5; Cell biology; Cancer; Gene expression; Cellular differentiation; Transcription factor; Gene; Metastasis; Adult stem cell; Embryonic stem cell; Induced pluripotent stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006590183,0.0002368547,0.0001508137,0.0001545811,0.0001404438,0.0002740301,0.00009283044,0.0001313422,0.00119436],"category_scores_gemma":[0.00006379829,0.00009749026,0.0002277532,0.00008558709,0.0001762058,0.0001442929,0.0002006995,0.0002520341,0.0003253539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002928327,"about_ca_system_score_gemma":0.0001994281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007737103,"about_ca_topic_score_gemma":0.001317613,"domain_scores_codex":[0.9999216,0.00001112617,0.000004406751,0.00001757016,0.00001742947,0.0000279367],"domain_scores_gemma":[0.9999484,0.000004664926,0.00001853485,0.000004019248,0.000007372041,0.00001701358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009692591,0.000008111398,0.0005288184,0.00002570288,0.000004222562,0.00005148747,0.0000136474,0.00004755695,0.9984812,0.00006972728,0.00004888758,0.0006238165],"study_design_scores_gemma":[0.00001913985,0.0002394471,0.04296016,0.0000130377,0.0000398253,0.0003026349,0.0001937983,0.002803656,0.9504631,0.0001465539,0.002809073,0.000009539332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965173,0.0006203125,0.001136326,0.00008627312,0.00001369574,0.00001194443,0.0003676087,0.00006830189,0.001178308],"genre_scores_gemma":[0.9978442,0.000234318,0.0004033664,0.00003750061,0.000002711741,0.00001209504,0.000282031,0.000007356648,0.0011763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00119436,"threshold_uncertainty_score":0.003995538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007634648844543182,"score_gpt":0.2380600477639219,"score_spread":0.2304253989193787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}