{"id":"W4311052269","doi":"10.3390/biomedicines10123094","title":"The Blood DNA Methylation Clock GrimAge Is a Robust Surrogate for Airway Epithelia Aging","year":2022,"lang":"en","type":"article","venue":"Biomedicines","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Institute of Circulatory and Respiratory Health; Canadian Institutes of Health Research; British Columbia Lung Association","keywords":"Epigenetics; DNA methylation; COPD; Airway; Pulmonary disease; Methylation; Biology; Medicine; Bioinformatics; DNA; Internal medicine; Genetics; Gene; Gene expression; Anesthesia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007086945,0.0001280169,0.0001109255,0.00005663617,0.0005569624,0.00002523003,0.0001942945,0.00005252183,0.00002483992],"category_scores_gemma":[0.0001044666,0.00009584295,0.00009326479,0.0001674775,0.00007830655,0.000002751898,0.0001202489,0.00006475009,0.000002036992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001239207,"about_ca_system_score_gemma":0.00004964453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002248166,"about_ca_topic_score_gemma":0.0000166991,"domain_scores_codex":[0.998968,0.00008466941,0.0002338427,0.0002877558,0.0001944402,0.000231272],"domain_scores_gemma":[0.9993426,0.00007063576,0.0001281784,0.0003001427,0.0001053229,0.00005317357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005730393,0.00004619934,0.001050641,0.00002098948,0.00007685275,0.000001061159,0.0001542861,0.0001091206,0.9730582,0.0001305241,0.002769554,0.0225253],"study_design_scores_gemma":[0.000900519,0.0005028015,0.00169903,0.000006730007,0.0000719419,0.000003307911,0.0001924419,0.0003926095,0.5356966,0.0005371646,0.4598377,0.0001591212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9630142,0.02053392,0.009424299,0.004704189,0.001053286,0.0006204502,0.0001372489,0.00002845747,0.0004839094],"genre_scores_gemma":[0.990968,0.001241285,0.001233522,0.0004291462,0.0008710925,0.000199033,0.0003329878,0.00003908827,0.004685835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4570682,"threshold_uncertainty_score":0.4283761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01610100191125678,"score_gpt":0.2640373904279837,"score_spread":0.247936388516727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}