{"id":"W4311052269","doi":"10.3390/biomedicines10123094","title":"The Blood DNA Methylation Clock GrimAge Is a Robust Surrogate for Airway Epithelia Aging","year":2022,"lang":"en","type":"article","venue":"Biomedicines","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Institute of Circulatory and Respiratory Health; Canadian Institutes of Health Research; British Columbia Lung Association","keywords":"Epigenetics; DNA methylation; COPD; Airway; Pulmonary disease; Methylation; Biology; Medicine; Bioinformatics; DNA; Internal medicine; Genetics; Gene; Gene expression; Anesthesia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001140594,0.0003489386,0.0005131441,0.0008608826,0.0003083304,0.0008775778,0.0003347413,0.0006807885,0.00150397],"category_scores_gemma":[0.002432293,0.0002159511,0.0003005223,0.0009802062,0.0002958073,0.0003834334,0.0005374521,0.000603969,0.0004808884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003121343,"about_ca_system_score_gemma":0.0002594196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001427749,"about_ca_topic_score_gemma":0.002514966,"domain_scores_codex":[0.999077,0.0002755526,0.0000599782,0.0003305768,0.0001765777,0.00008020324],"domain_scores_gemma":[0.9988819,0.0003026193,0.0004231091,0.0001339736,0.0001749568,0.00008347687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001398458,0.00007707757,0.7621296,0.0003659265,0.0005359032,0.0001647462,0.0005647258,0.0006977994,0.1842378,0.0009958962,0.001068182,0.04776401],"study_design_scores_gemma":[0.00001425101,0.000550515,0.9290155,0.00005943367,0.0002159162,0.0006444596,0.0002740933,0.002775312,0.05801533,0.001154535,0.007241184,0.00003941975],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9494944,0.009521361,0.0306625,0.0003122322,0.000212476,0.00008772196,0.00509076,0.0002574021,0.004361267],"genre_scores_gemma":[0.989493,0.0008245927,0.006709376,0.0001749078,0.00005148453,0.00005889482,0.001392714,0.00003444681,0.001260647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00150397,"threshold_uncertainty_score":0.006032109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01610100191125678,"score_gpt":0.2640373904279837,"score_spread":0.247936388516727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}