{"id":"W4311057093","doi":"10.3389/fcell.2022.963608","title":"The unexpected versatility of ALP/Enigma family proteins","year":2022,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"PDZ domain; Multicellular organism; Biology; Context (archaeology); Protein family; Cytoskeleton; SUPERFAMILY; Computational biology; Function (biology); Model organism; Cell biology; Genetics; Receptor; Gene; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003482291,0.0005667477,0.0007629062,0.002283892,0.0002065264,0.0008306432,0.0004509582,0.0007065127,0.001965481],"category_scores_gemma":[0.0004003795,0.0001733943,0.000369909,0.001427685,0.0003817871,0.001391147,0.0005457524,0.001555508,0.001194493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003916999,"about_ca_system_score_gemma":0.0006177217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005116672,"about_ca_topic_score_gemma":0.000868505,"domain_scores_codex":[0.9998937,0.00001304492,0.00001833897,0.00002535368,0.00003831125,0.00001135636],"domain_scores_gemma":[0.9998482,0.00006704773,0.00002010671,0.000005251148,0.00004313921,0.00001613028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007264589,0.00002926252,0.0002260179,0.01244391,0.00009708319,0.000505097,0.0000986903,0.0002972619,0.004982234,0.004743032,0.01987323,0.9566315],"study_design_scores_gemma":[0.00001001196,0.00004717162,0.0009757084,0.001368548,0.00007847207,0.002914466,0.00004341458,0.00006050404,0.0007905899,0.001512266,0.9921845,0.0000144228],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000262987,0.9979551,0.0001965831,0.0003017652,0.0001506095,0.000002564807,0.00002202215,0.000008848378,0.001099482],"genre_scores_gemma":[0.001167514,0.9974434,0.0002780194,0.0001993507,0.0001732535,0.000004674697,0.00004844711,0.000002434001,0.0006829252],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002283892,"threshold_uncertainty_score":0.006575227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03408928426548968,"score_gpt":0.2827086199485664,"score_spread":0.2486193356830768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}