{"id":"W4311057093","doi":"10.3389/fcell.2022.963608","title":"The unexpected versatility of ALP/Enigma family proteins","year":2022,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"PDZ domain; Multicellular organism; Biology; Context (archaeology); Protein family; Cytoskeleton; SUPERFAMILY; Computational biology; Function (biology); Model organism; Cell biology; Genetics; Receptor; Gene; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003614093,0.0002656679,0.001454087,0.0001491607,0.0001744364,0.000004747925,0.0001315761,0.0001933172,0.000021227],"category_scores_gemma":[0.00007663114,0.0001686485,0.0002071937,0.0002990656,0.0003676171,0.00001204797,0.0003072744,0.0003617397,0.000002453187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002707574,"about_ca_system_score_gemma":0.0003898739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006022009,"about_ca_topic_score_gemma":0.000009118003,"domain_scores_codex":[0.9985068,0.0002112811,0.0005434514,0.0003645882,0.0001093393,0.000264542],"domain_scores_gemma":[0.9994043,0.0001811713,0.000175741,0.0001704488,0.00001933094,0.00004899432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001267204,0.00006413857,0.002347837,0.002941695,0.0003193689,0.00002728429,0.0005350008,7.509261e-9,0.00001746149,0.00001669346,0.006880658,0.9867231],"study_design_scores_gemma":[0.0004985174,0.0001317657,0.0006180293,0.0003937648,0.000185023,0.00003803817,0.002220168,3.106979e-7,0.00001635572,0.00005559356,0.9956793,0.0001631437],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000687014,0.9891487,0.00002957651,0.00001551394,0.0009163167,0.001019891,0.00006113615,0.00001519618,0.008106652],"genre_scores_gemma":[0.0002620553,0.9965754,0.002134276,0.00003301598,0.00003393961,0.0002660423,0.0001741191,0.00001502399,0.0005061544],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9887986,"threshold_uncertainty_score":0.6877287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03408928426548968,"score_gpt":0.2827086199485664,"score_spread":0.2486193356830768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}