{"id":"W4311070372","doi":"10.1002/ange.202215422","title":"Dearomatization of Biaryls through Polarity Mismatched Radical Spirocyclization","year":2022,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Radical Photochemical Reactions","field":"Chemistry","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Regioselectivity; Nucleophile; Chemistry; Combinatorial chemistry; Chemical space; Natural product; Functional group; Redox; Stereochemistry; Organic chemistry; Catalysis; Drug discovery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001131533,0.0001559173,0.0002486092,0.00003583149,0.0001881835,0.00001474804,0.0002838667,0.0001298623,0.005285168],"category_scores_gemma":[0.0003192857,0.0001714681,0.0001316957,0.0003695661,0.0001265151,0.0001432947,0.0001465601,0.000363319,0.00001052389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002185659,"about_ca_system_score_gemma":0.00006962344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001605425,"about_ca_topic_score_gemma":0.000003832532,"domain_scores_codex":[0.9985284,0.00002167164,0.0003959134,0.0003001907,0.0005135149,0.0002403439],"domain_scores_gemma":[0.9991329,0.0001453523,0.0002038532,0.0003629334,0.0000486332,0.000106345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003309665,0.0002384029,0.001169112,0.0000929446,0.0000349126,0.000003880492,0.0002256545,0.000025806,0.9949129,0.0004125551,0.00273187,0.0001189233],"study_design_scores_gemma":[0.0005286214,0.00001367184,0.00009757377,0.00001914602,0.00004120919,0.00001828857,0.0001474898,0.0000973405,0.9681299,0.002972753,0.02776575,0.0001682341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9642644,0.0002317109,0.0006301945,0.000638475,0.00008555279,0.0001357543,0.0001243544,0.0001747371,0.03371482],"genre_scores_gemma":[0.9976491,0.00002639267,0.0009123993,0.0002001368,0.0001042547,0.00007708498,0.0005022719,0.00003241897,0.0004959924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03338465,"threshold_uncertainty_score":0.9956241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01955630157460714,"score_gpt":0.2565669217553473,"score_spread":0.2370106201807402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}