{"id":"W4311086202","doi":"10.1038/s41588-022-01205-w","title":"K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas","year":2022,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":158,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill Genome Centre; Montreal Children's Hospital; Université Laval; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Hospital for Sick Children; McGill University Health Centre; McGill University; SickKids Foundation; University of Toronto; Jewish General Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Cancer Institute; Brain Research UK","keywords":"Biology; Chromatin; Histone H3; Epigenomics; Genetics; Epigenetics; Transcriptome; Mutation; Histone; Cell biology; DNA methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003685566,0.0002363218,0.0004641816,0.0003705635,0.00004763812,0.0000181412,0.0001489988,0.0003147875,0.0000910768],"category_scores_gemma":[0.0001515056,0.0002231648,0.00006571104,0.0007146782,0.00006386507,0.00001991053,0.0002349687,0.001235139,0.000003314695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003051506,"about_ca_system_score_gemma":0.000315872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002903301,"about_ca_topic_score_gemma":0.005267652,"domain_scores_codex":[0.9980142,0.0001590716,0.0004623173,0.0005185807,0.000405933,0.0004398935],"domain_scores_gemma":[0.9991789,0.0002594303,0.00007068479,0.0002944369,0.00002817066,0.0001683492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004292057,0.002270737,0.9827484,0.00006187535,0.00002372651,0.00764519,0.0003203401,0.0005871379,0.002114945,0.00008359535,0.001339808,0.002375047],"study_design_scores_gemma":[0.01000472,0.0007113984,0.9735685,0.00006879408,0.00005379245,0.0002640249,0.0001031638,0.002125299,0.003041278,0.00006716444,0.009730826,0.0002610633],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879397,0.007842739,0.000001225917,0.002859661,0.0002463468,0.0005167224,0.0001074313,0.00001489519,0.0004712837],"genre_scores_gemma":[0.9977138,0.0002037205,0.0008345849,0.0007931648,0.0001521756,0.00008767622,0.00009675431,0.00003120784,0.00008690444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009774116,"threshold_uncertainty_score":0.9100398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008924336558614337,"score_gpt":0.280216542590572,"score_spread":0.2712922060319576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}