{"id":"W4311089805","doi":"10.1016/j.antiviral.2022.105484","title":"Discovery of lead natural products for developing pan-SARS-CoV-2 therapeutics","year":2022,"lang":"en","type":"article","venue":"Antiviral Research","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Centre for Disease Control; Université de Sherbrooke; Simon Fraser University; University of British Columbia","funders":"Mitacs; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Genome British Columbia","keywords":"Bafilomycin; Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Vero cell; EC50; Monoclonal antibody; Cell culture; Chemistry; Microbiology; In vitro; Coronavirus disease 2019 (COVID-19); Biology; Virus; Medicine; Biochemistry; Antibody; Immunology; Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001697777,0.0003682853,0.0002767707,0.0003088727,0.0001022615,0.0002994299,0.000156489,0.0003025067,0.001536556],"category_scores_gemma":[0.0001108666,0.000139323,0.0003463657,0.0001694222,0.0001248992,0.0002232613,0.0002178645,0.0003316948,0.0005282563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002194456,"about_ca_system_score_gemma":0.0001981457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002431255,"about_ca_topic_score_gemma":0.0008748331,"domain_scores_codex":[0.9999294,0.00001363187,0.000004715947,0.00001240004,0.00002440669,0.00001536671],"domain_scores_gemma":[0.999957,0.00000828359,0.00000979067,0.000003928086,0.00001040547,0.0000107115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000106455,0.00008177475,0.0002196313,0.0002037144,0.00001549336,0.0001593642,0.00002557719,0.0008067881,0.9871674,0.0003584865,0.0001585258,0.01069673],"study_design_scores_gemma":[0.0000998683,0.002609858,0.003135591,0.00007018455,0.00006580489,0.0005891008,0.00007916055,0.001777564,0.9690431,0.0004302352,0.02208002,0.00001945719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9472166,0.01544604,0.02309075,0.0004603591,0.0000874381,0.000465252,0.001644642,0.0002796904,0.01130937],"genre_scores_gemma":[0.9680864,0.007510138,0.01816885,0.0002621597,0.00001989435,0.0001394611,0.001115185,0.00002619541,0.00467173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001536556,"threshold_uncertainty_score":0.005140245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2106674548316415,"score_gpt":0.4596793827760708,"score_spread":0.2490119279444293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}