{"id":"W4311098240","doi":"10.1158/1538-7445.cancepi22-pr004","title":"Abstract PR004: High-density CRISPR screens reveal mechanisms of chromatin regulation of stemness networks in acute myeloid leukemia","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute","funders":"","keywords":"Biology; Chromatin; CRISPR; Epigenetics; Myeloid leukemia; Cancer research; Genetics; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001783283,0.0004395879,0.0003965916,0.0003566774,0.000163103,0.0003724997,0.000414583,0.0003034767,0.003624739],"category_scores_gemma":[0.0001759045,0.0001914479,0.0002670086,0.0002175513,0.0002074058,0.000140475,0.0003586248,0.0005359118,0.0007462569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004047185,"about_ca_system_score_gemma":0.0002104464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007193948,"about_ca_topic_score_gemma":0.001712521,"domain_scores_codex":[0.9997614,0.00002363638,0.00001907572,0.00005947627,0.000101214,0.0000352007],"domain_scores_gemma":[0.9998745,0.00003437321,0.00003553895,0.00001672051,0.00001115644,0.0000276493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005937731,0.00001353331,0.0002584009,0.00002510623,0.000005585666,0.00004156891,0.000006271425,0.0002257478,0.9972511,0.0001078582,0.00009238072,0.001913218],"study_design_scores_gemma":[0.0000246503,0.0001866762,0.005886324,0.000005616073,0.00002370431,0.0002785601,0.00001812709,0.003260005,0.9864064,0.0001076047,0.003794042,0.000008162616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9482186,0.0006661647,0.03795448,0.0002286943,0.00002574718,0.0001655449,0.005600882,0.00205264,0.005087274],"genre_scores_gemma":[0.9733301,0.0002725302,0.01741871,0.0001121574,0.000006065921,0.0000829221,0.003334993,0.0001867729,0.005255749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003624739,"threshold_uncertainty_score":0.01212597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0207354049729865,"score_gpt":0.3516774613363394,"score_spread":0.3309420563633529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}