{"id":"W4311098666","doi":"10.1158/2326-6074.tumimm22-a51","title":"Abstract A51: STING activation overcomes immune escape in osteosarcoma metastasis","year":2022,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Sting; Stimulator of interferon genes; Cancer research; Metastasis; Immune system; Cancer; Tumor microenvironment; Cancer cell; Immunotherapy; Medicine; Downregulation and upregulation; Innate immune system; Immunology; Biology; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001354682,0.0003128782,0.0003205286,0.0002752513,0.0001248842,0.0003051382,0.0001934792,0.0002734426,0.004132571],"category_scores_gemma":[0.000117452,0.00009310437,0.0003055796,0.0001333595,0.0001833662,0.0002031461,0.0001784601,0.0008512175,0.000592495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002044521,"about_ca_system_score_gemma":0.0002993745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005037426,"about_ca_topic_score_gemma":0.0008844727,"domain_scores_codex":[0.9998951,0.00001530577,0.00001200634,0.00001756308,0.00002122137,0.00003876568],"domain_scores_gemma":[0.9999361,0.000007277286,0.00001344703,0.000007796317,0.000006611313,0.00002884067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008654267,0.0003769821,0.0003790074,0.0001470689,0.00002121274,0.00009352809,0.00002047242,0.0002672886,0.9844258,0.0004355311,0.0005665721,0.01240101],"study_design_scores_gemma":[0.0004019028,0.01100504,0.007843985,0.00004514426,0.0001173437,0.0005161184,0.00007643234,0.003069141,0.9614599,0.0003114589,0.01513854,0.00001495756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893872,0.003829655,0.001673335,0.0002958424,0.0002365992,0.00009421037,0.0004133498,0.000220894,0.003849021],"genre_scores_gemma":[0.9945465,0.001165404,0.0005935958,0.00009395383,0.00002939716,0.0000436678,0.0004050123,0.00001275197,0.00310968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004132571,"threshold_uncertainty_score":0.01382482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0800805621876029,"score_gpt":0.3771898084921618,"score_spread":0.2971092463045589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}