{"id":"W4311098671","doi":"10.1158/1538-7445.cancepi22-a010","title":"Abstract A010: Methylation profiling reveals the role of PRC2 in regulating DNA methylome stochasticity in malignant peripheral nerve sheath tumors","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"PRC2; Biology; Epigenetics; DNA methylation; Cancer research; Methylation; Genetics; CpG site; Carcinogenesis; EZH2; Cancer; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001546045,0.0001572439,0.0001225502,0.0003000769,0.000130789,0.0002642396,0.0001507004,0.000165568,0.001327928],"category_scores_gemma":[0.0001712393,0.0001075978,0.0001343463,0.0002181992,0.000132899,0.0001193528,0.0001620143,0.0002736961,0.0004192998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001567972,"about_ca_system_score_gemma":0.00009330346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001239527,"about_ca_topic_score_gemma":0.001475372,"domain_scores_codex":[0.9998935,0.00001069533,0.000007539631,0.00003288982,0.00003735851,0.00001802399],"domain_scores_gemma":[0.9998852,0.00002409194,0.00002527488,0.00001481306,0.00002601623,0.00002461413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006766627,0.000007026419,0.002495822,0.00001267828,0.000004570138,0.0000166483,0.00001425079,0.00007226328,0.9955335,0.00004205876,0.000035018,0.001698484],"study_design_scores_gemma":[0.000006345564,0.0001346729,0.06295542,0.000002909142,0.00002044803,0.0002401282,0.00003234705,0.002440906,0.9322321,0.00007516936,0.001852427,0.000007034309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887292,0.001170308,0.007355635,0.00009785156,0.00001527033,0.0000155443,0.001106414,0.0001305897,0.001379097],"genre_scores_gemma":[0.9924959,0.0004075578,0.003642535,0.0000266005,0.000007102804,0.00001279177,0.0009239936,0.00002453895,0.002459058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001327928,"threshold_uncertainty_score":0.004442394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07100068802872331,"score_gpt":0.376066777237656,"score_spread":0.3050660892089326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}