{"id":"W4311106676","doi":"10.3390/cells11233896","title":"The Dynamics of Cryptococcus neoformans Cell and Transcriptional Remodeling during Infection","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ministério da Saúde; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Cryptococcus neoformans; Biology; Cryptococcosis; Downregulation and upregulation; Ribosome biogenesis; Immune system; Phenotype; Phenotypic switching; Proteasome; Virulence; Cell biology; Cell; Microbiology; Immunology; Ribosome; Genetics; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001101511,0.00004647137,0.00007685108,0.00003757249,0.0005224974,0.00000603356,0.00001646218,0.00001369322,0.00004034347],"category_scores_gemma":[0.000003392633,0.00003540088,0.00004344235,0.00008123118,0.00003894163,0.00002490417,0.00003004755,0.0001319209,0.000001375183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005831776,"about_ca_system_score_gemma":0.00001535148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006906192,"about_ca_topic_score_gemma":0.00003113623,"domain_scores_codex":[0.9996141,0.00001466069,0.0001200362,0.00006970211,0.00009370862,0.00008777787],"domain_scores_gemma":[0.9998201,0.00002457926,0.00003136887,0.0000704678,0.0000335452,0.00001993704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005575737,0.0005616487,0.05166012,0.0007444542,0.0001815258,0.000009358261,0.004716889,0.02625183,0.8944585,0.01273083,0.001110476,0.007016815],"study_design_scores_gemma":[0.008573886,0.002755485,0.4665372,0.0001625671,0.0006739114,0.0004082619,0.009922449,0.3119588,0.1136043,0.002664826,0.08188358,0.0008548291],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937485,0.0004408551,0.0005959897,0.000204322,0.0002597212,0.0001569445,0.00001168882,0.00001638733,0.004565628],"genre_scores_gemma":[0.9977545,0.0004735222,0.00008258375,0.00002166854,0.00003287361,0.00001830189,0.000005908807,0.000005712549,0.001604907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7808542,"threshold_uncertainty_score":0.401868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008718231566551249,"score_gpt":0.2184139720476436,"score_spread":0.2096957404810924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}