{"id":"W4311106676","doi":"10.3390/cells11233896","title":"The Dynamics of Cryptococcus neoformans Cell and Transcriptional Remodeling during Infection","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ministério da Saúde; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Cryptococcus neoformans; Biology; Cryptococcosis; Downregulation and upregulation; Ribosome biogenesis; Immune system; Phenotype; Phenotypic switching; Proteasome; Virulence; Cell biology; Cell; Microbiology; Immunology; Ribosome; Genetics; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001280304,0.0002042577,0.0002167729,0.0003518355,0.0001473283,0.000279068,0.00008488912,0.000271421,0.0008432407],"category_scores_gemma":[0.0001191356,0.00009978977,0.0001479222,0.0002269198,0.0002301354,0.0001748032,0.0001545473,0.0004060181,0.0002869537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002225803,"about_ca_system_score_gemma":0.0001529443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005250118,"about_ca_topic_score_gemma":0.0005869869,"domain_scores_codex":[0.9998415,0.00002077026,0.000008241346,0.00003733039,0.00003959813,0.00005262235],"domain_scores_gemma":[0.9998955,0.00001773687,0.00002541,0.000009814494,0.0000176734,0.00003395049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002207958,0.00002281598,0.001464951,0.00002081012,0.000002306753,0.00006525468,0.0000415135,0.00004492375,0.9966126,0.0000423624,0.00002074777,0.001440979],"study_design_scores_gemma":[0.00001551342,0.0006532718,0.1282504,0.00001820369,0.00002242398,0.0004131363,0.0003467186,0.001366352,0.8662592,0.0002033438,0.002432691,0.00001887692],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995382,0.001147725,0.001390777,0.00005527294,0.00001405966,0.00002831551,0.0007321208,0.00005025297,0.001199571],"genre_scores_gemma":[0.9961349,0.0006252391,0.001160899,0.00005126068,0.000009871377,0.00004467873,0.0005006532,0.000008328031,0.001464264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008432407,"threshold_uncertainty_score":0.002820849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008718231566551249,"score_gpt":0.2184139720476436,"score_spread":0.2096957404810924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}