{"id":"W4311111624","doi":"10.3390/ddc1010003","title":"Failed Repurposing of Lysosomotropic Drugs for COVID-19 Treatment or Prevention","year":2022,"lang":"en","type":"article","venue":"Drugs and Drug Candidates","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Phospholipidosis; Pharmacology; Repurposing; Drug repositioning; Hydroxychloroquine; Drug; Endocytosis; Microvesicles; Medicine; Coronavirus disease 2019 (COVID-19); Chemistry; Biology; Disease; Cell; Pathology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002515273,0.0004216057,0.00141979,0.0006721129,0.0003770789,0.0009415307,0.0005919343,0.001009341,0.002504769],"category_scores_gemma":[0.001825168,0.0001326599,0.000757119,0.0003698677,0.0005984266,0.0007029119,0.0004738814,0.001253356,0.000911666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005958945,"about_ca_system_score_gemma":0.0007250634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003574713,"about_ca_topic_score_gemma":0.0006182657,"domain_scores_codex":[0.9992973,0.0002845153,0.0001262097,0.00007022249,0.0001358273,0.00008605939],"domain_scores_gemma":[0.9990663,0.0003754161,0.0001693492,0.00008281948,0.0001974965,0.0001087129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.006721083,0.002517749,0.005314322,0.006784846,0.0006416314,0.002989301,0.0004465854,0.0007714237,0.1913865,0.007892334,0.006196678,0.7683375],"study_design_scores_gemma":[0.003583578,0.08079963,0.02147571,0.003514564,0.001745807,0.01276989,0.0007764783,0.00160422,0.3959513,0.005531326,0.4721107,0.0001367583],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.3498617,0.6128423,0.007221611,0.005951474,0.001162963,0.001483696,0.0007489076,0.0002733985,0.02045395],"genre_scores_gemma":[0.7651327,0.2110678,0.01017761,0.004490075,0.0007753742,0.0005631566,0.001248305,0.00007977773,0.00646518],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002515273,"threshold_uncertainty_score":0.01330221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0431918929892267,"score_gpt":0.4119759014350396,"score_spread":0.3687840084458129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}