{"id":"W4311111624","doi":"10.3390/ddc1010003","title":"Failed Repurposing of Lysosomotropic Drugs for COVID-19 Treatment or Prevention","year":2022,"lang":"en","type":"article","venue":"Drugs and Drug Candidates","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Phospholipidosis; Pharmacology; Repurposing; Drug repositioning; Hydroxychloroquine; Drug; Endocytosis; Microvesicles; Medicine; Coronavirus disease 2019 (COVID-19); Chemistry; Biology; Disease; Cell; Pathology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006089956,0.0001646677,0.0005040235,0.0001507825,0.0004219362,0.00001994265,0.00008568429,0.00002981633,0.0003970154],"category_scores_gemma":[0.002861773,0.0001162403,0.0001781049,0.000220939,0.0001436225,0.0000518826,0.0001995095,0.0001098918,0.000001570885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004482154,"about_ca_system_score_gemma":0.0007238077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007051568,"about_ca_topic_score_gemma":0.00006940488,"domain_scores_codex":[0.9983817,0.0001263224,0.0004185296,0.0004076399,0.0003719879,0.0002937702],"domain_scores_gemma":[0.9963005,0.002902929,0.000160621,0.000284481,0.0000805768,0.0002709559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.04060123,0.007023851,0.2206376,0.01347119,0.004127489,0.0002814025,0.08167329,0.000775779,0.009138329,0.004947938,0.03490618,0.5824157],"study_design_scores_gemma":[0.02520884,0.008156945,0.00457103,0.0002376509,0.0009911333,0.00001055913,0.01159211,0.004245909,0.006779797,0.004472023,0.9331926,0.0005414458],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796892,0.001846033,0.0003525196,0.01450705,0.000144178,0.002601746,0.0003246678,0.00009138136,0.000443151],"genre_scores_gemma":[0.9829037,0.0009391569,0.0003982941,0.0007082205,0.00008905539,0.0005840925,0.000115912,0.00002057032,0.01424097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8982863,"threshold_uncertainty_score":0.4740143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0431918929892267,"score_gpt":0.4119759014350396,"score_spread":0.3687840084458129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}