{"id":"W4311115611","doi":"10.1016/s0140-6736(22)02303-0","title":"Bimekizumab in patients with active psoriatic arthritis and previous inadequate response or intolerance to tumour necrosis factor-α inhibitors: a randomised, double-blind, placebo-controlled, phase 3 trial (BE COMPLETE)","year":2022,"lang":"en","type":"article","venue":"The Lancet","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":158,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"UCB Pharma; Manchester Biomedical Research Centre; National Institute for Health and Care Research","keywords":"Medicine; Psoriatic arthritis; Placebo; Double blind; Psoriasis; Internal medicine; Arthritis; Dermatology; Gastroenterology; Oncology; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005777827,0.0003310976,0.001502367,0.0001717293,0.0004022948,0.00006030162,0.0001664396,0.00004304809,0.0001411198],"category_scores_gemma":[0.0003027153,0.0002019497,0.0001024131,0.0004629075,0.00009199769,0.00009655444,0.0001684032,0.0003727846,0.000008435183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002660828,"about_ca_system_score_gemma":0.0001358054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002838208,"about_ca_topic_score_gemma":0.0004190833,"domain_scores_codex":[0.9974614,0.0005327955,0.0005191354,0.0004515787,0.0005307847,0.0005043457],"domain_scores_gemma":[0.9984919,0.000621018,0.0002346142,0.0004219536,0.00007978098,0.0001507501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9669397,0.001041191,0.0005808323,0.00002159959,0.0003535739,0.0001410016,0.003815515,0.00001622582,0.00004000957,0.000005144038,0.0007368319,0.02630838],"study_design_scores_gemma":[0.9788145,0.01066554,0.007007201,0.0002722374,0.0001678564,0.00002759709,0.0004889635,0.00002381204,0.00009394116,0.00001691724,0.002183659,0.0002377871],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851772,0.0006679771,0.000004242454,0.003314831,0.0002973884,0.01000366,0.0004116788,0.00004803766,0.00007497273],"genre_scores_gemma":[0.994669,0.0001710367,0.00007031871,0.0007418631,0.0003397033,0.003746348,0.00005334349,0.00004023535,0.0001681443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0260706,"threshold_uncertainty_score":0.823527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04186891445719548,"score_gpt":0.3044154919088538,"score_spread":0.2625465774516583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}