{"id":"W4311119330","doi":"10.1093/braincomms/fcac318","title":"Serum unsaturated phosphatidylcholines predict longitudinal basal forebrain degeneration in Alzheimer’s disease","year":2022,"lang":"en","type":"article","venue":"Brain Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph's Hospital; Lawson Health Research Institute; Western University","funders":"Janssen Alzheimer Immunotherapy Research And Development; Johnson and Johnson Pharmaceutical Research and Development; National Institute on Aging; Eisai Incorporated; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; Grifols; IXICO; H. Lundbeck A/S; Servier; Eisai; National Institute of Environmental Health Sciences; Lundbeck Canada; Northern California Institute for Research and Education; GE Healthcare; DoD Alzheimer's Disease Neuroimaging Initiative; Pfizer; BioClinica; Biogen; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Roche; Merck; Alzheimer's Drug Discovery Foundation; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Basal forebrain; Cholinergic neuron; Internal medicine; Cholinergic; Lipidomics; Phosphatidylcholine; Endocrinology; Psychology; Pathology; Neuroscience; Biology; Medicine; Biochemistry; Phospholipid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007570548,0.0003963975,0.0003423132,0.0006515743,0.0003637166,0.0005118733,0.0002388758,0.0006093517,0.001123417],"category_scores_gemma":[0.002043658,0.0002084774,0.0002960627,0.0004339936,0.0002377123,0.0004678335,0.0004188472,0.0005583705,0.0002197165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002242149,"about_ca_system_score_gemma":0.0002049776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002240825,"about_ca_topic_score_gemma":0.001946317,"domain_scores_codex":[0.9997953,0.00004473647,0.00003843578,0.00005668561,0.00003785584,0.00002707368],"domain_scores_gemma":[0.9986261,0.0002907943,0.0005318252,0.00008926664,0.0002316703,0.0002304107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004920337,0.00004183904,0.9971788,0.000006570824,0.0000364579,0.00006082629,0.00003473947,0.0000565447,0.001061391,0.00001236995,0.00004272205,0.000975766],"study_design_scores_gemma":[0.000008435273,0.0002164815,0.9981952,0.000005424595,0.00003023067,0.0002862126,0.00008198002,0.0006315366,0.0004028542,0.00007124144,0.00006734379,0.000003033671],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999388,0.0001403547,0.0001131634,0.00002879269,0.000003774215,0.000004202867,0.0001279933,0.00000421204,0.0001895389],"genre_scores_gemma":[0.9996229,0.00003080695,0.0001246935,0.000009639593,0.000003259572,0.000002768475,0.0001150588,8.815626e-7,0.00008991154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002240825,"threshold_uncertainty_score":0.004455566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0777823360440851,"score_gpt":0.3559459471680075,"score_spread":0.2781636111239224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}