{"id":"W4311119330","doi":"10.1093/braincomms/fcac318","title":"Serum unsaturated phosphatidylcholines predict longitudinal basal forebrain degeneration in Alzheimer’s disease","year":2022,"lang":"en","type":"article","venue":"Brain Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph's Hospital; Lawson Health Research Institute; Western University","funders":"Janssen Alzheimer Immunotherapy Research And Development; Johnson and Johnson Pharmaceutical Research and Development; National Institute on Aging; Eisai Incorporated; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; Grifols; IXICO; H. Lundbeck A/S; Servier; Eisai; National Institute of Environmental Health Sciences; Lundbeck Canada; Northern California Institute for Research and Education; GE Healthcare; DoD Alzheimer's Disease Neuroimaging Initiative; Pfizer; BioClinica; Biogen; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Roche; Merck; Alzheimer's Drug Discovery Foundation; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Basal forebrain; Cholinergic neuron; Internal medicine; Cholinergic; Lipidomics; Phosphatidylcholine; Endocrinology; Psychology; Pathology; Neuroscience; Biology; Medicine; Biochemistry; Phospholipid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004041128,0.000192304,0.0002146522,0.0002500287,0.0006278973,0.00004281948,0.0005071425,0.00003438177,0.0004618372],"category_scores_gemma":[0.0002649692,0.000192646,0.0001190008,0.0007445167,0.0001658089,0.0001927562,0.0005294599,0.0004224629,0.00003924081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002005379,"about_ca_system_score_gemma":0.0008037097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001356536,"about_ca_topic_score_gemma":0.000236095,"domain_scores_codex":[0.9980118,0.0004733437,0.0003589735,0.0003388053,0.0004442421,0.0003728857],"domain_scores_gemma":[0.9973269,0.0002972531,0.00009127595,0.001649905,0.0001303041,0.0005044237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001826268,0.004767504,0.943647,0.0000488585,0.002951051,0.0002722733,0.0004877332,0.001205419,0.0001535861,0.007558089,0.03040743,0.006674751],"study_design_scores_gemma":[0.003972626,0.0002637253,0.9400199,0.00008633234,0.0007053894,0.00001991816,0.0003002718,0.04245516,0.0001596936,0.001659406,0.01000878,0.0003487899],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7697184,0.08396492,0.00009691261,0.1376115,0.0002102502,0.004111829,0.001695231,0.0003755015,0.002215498],"genre_scores_gemma":[0.9927297,0.0003574662,0.0007818567,0.001238729,0.00005695318,0.001053084,0.003576567,0.00003872226,0.0001668846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2230113,"threshold_uncertainty_score":0.7855877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0777823360440851,"score_gpt":0.3559459471680075,"score_spread":0.2781636111239224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}