{"id":"W4311119341","doi":"10.1038/s41467-022-35070-2","title":"DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Christie (Canada)","funders":"School of Medicine, University of California, San Diego; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; University of California, San Diego; Fondation Leducq; Deutsche Forschungsgemeinschaft; Cardio-Pulmonary Institute; Deutsches Zentrum für Herz-Kreislaufforschung; Francis Crick Institute","keywords":"Biology; Embryonic stem cell; Cell biology; Gene silencing; Cell cycle; Gene; Regulation of gene expression; Histone; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001097847,0.0002738214,0.0002122001,0.0002069502,0.0001748228,0.0002969223,0.0001894855,0.0002121795,0.0009475464],"category_scores_gemma":[0.0001249325,0.0001770596,0.0001396632,0.00007983774,0.0002803718,0.0001951418,0.0003756835,0.0003687942,0.0004498803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004053372,"about_ca_system_score_gemma":0.0002196097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005627619,"about_ca_topic_score_gemma":0.001524699,"domain_scores_codex":[0.9998558,0.00001185048,0.000009913062,0.00004768168,0.00003775631,0.00003695485],"domain_scores_gemma":[0.9998519,0.00001862963,0.00004792174,0.00001481131,0.00001663936,0.00005002972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002446635,0.000003522958,0.0004100406,0.000008236941,8.206592e-7,0.00002917897,0.00001102394,0.00002699226,0.9988696,0.00005659285,0.00001232359,0.000547132],"study_design_scores_gemma":[0.00001085319,0.00006603766,0.03005428,0.000006143127,0.000007384475,0.0001988073,0.00005001561,0.001578854,0.9660181,0.00006298745,0.001940922,0.000005640515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946551,0.0008014079,0.002851875,0.00007353407,0.00001162104,0.00001010063,0.0002845529,0.00008109006,0.001230681],"genre_scores_gemma":[0.9946284,0.0003157722,0.0009996853,0.00005105815,0.00000459342,0.00002023769,0.0005517305,0.00003497552,0.0033936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009475464,"threshold_uncertainty_score":0.003169835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007331271832489251,"score_gpt":0.2463027687189386,"score_spread":0.2389714968864493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}