{"id":"W4311123087","doi":"10.1186/s13063-022-06904-7","title":"Surrogate endpoints in trials: a call for better reporting","year":2022,"lang":"en","type":"letter","venue":"Trials","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; University of Toronto","funders":"Medical Research Council","keywords":"Surrogate endpoint; Medicine; Protocol (science); Consolidated Standards of Reporting Trials; Clinical trial; Alternative medicine; Endpoint Determination; Randomized controlled trial; Clinical endpoint; Guideline; Research design; Family medicine; Medical physics; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","insufficient_payload"],"consensus_categories":["metaresearch","insufficient_payload"],"category_scores_codex":[0.4430542,0.000586213,0.01066829,0.001320936,0.0002418322,0.0002205784,0.0006868793,0.001074617,0.005479858],"category_scores_gemma":[0.328325,0.0007147063,0.0015531,0.0002898342,0.00005345,0.0003102482,0.0001475848,0.001580674,0.0009616321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00164301,"about_ca_system_score_gemma":0.0005375743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001581694,"about_ca_topic_score_gemma":0.0001531152,"domain_scores_codex":[0.9275207,0.01010272,0.05874345,0.001988041,0.0003192495,0.001325815],"domain_scores_gemma":[0.8723912,0.04960832,0.07615041,0.001573089,0.0001107721,0.0001662291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001003313,0.00003670901,0.0007792811,0.0008795495,0.0002422131,0.00004197094,0.0005827771,0.00002328556,0.000001787466,0.0007842264,0.996284,0.0002438896],"study_design_scores_gemma":[0.003217023,0.00009792596,0.0001689288,0.0001651333,0.00005675755,0.00001012313,0.0001041395,0.0001897019,0.000005997622,0.02056854,0.9747452,0.0006705158],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.003434197,0.002462115,0.0006199028,0.9704857,0.006433236,0.008516513,0.005437054,0.000108919,0.002502372],"genre_scores_gemma":[0.000376189,0.0001592288,0.004382652,0.9620294,0.01691746,0.005765163,0.002187082,0.0002437512,0.007939086],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1147292,"threshold_uncertainty_score":0.9998162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8534718288419137,"score_gpt":0.5669957380861,"score_spread":0.2864760907558137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}