{"id":"W4311123087","doi":"10.1186/s13063-022-06904-7","title":"Surrogate endpoints in trials: a call for better reporting","year":2022,"lang":"en","type":"letter","venue":"Trials","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; University of Toronto","funders":"Medical Research Council","keywords":"Surrogate endpoint; Medicine; Protocol (science); Consolidated Standards of Reporting Trials; Clinical trial; Alternative medicine; Endpoint Determination; Randomized controlled trial; Clinical endpoint; Guideline; Research design; Family medicine; Medical physics; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.7709494,0.004585106,0.01908841,0.01015601,0.005506636,0.04221745,0.02042467,0.09643468,0.009025379],"category_scores_gemma":[0.891529,0.005229065,0.01671282,0.01243686,0.07564321,0.08227659,0.02045046,0.1897608,0.01026242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.02976268,"about_ca_system_score_gemma":0.04218143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004509977,"about_ca_topic_score_gemma":0.003122112,"domain_scores_codex":[0.1502034,0.5923934,0.1266154,0.01697731,0.1107842,0.003026292],"domain_scores_gemma":[0.03043748,0.8199959,0.03881797,0.04702101,0.05772514,0.006002496],"domain_codex":"methods","domain_gemma":"reporting","domain_candidate":"reporting","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009915711,0.0001797512,0.001585285,0.008037307,0.001037764,0.0008118089,0.003169691,0.00141494,0.000416489,0.1865692,0.6695178,0.1262684],"study_design_scores_gemma":[0.001547935,0.0004510088,0.001342173,0.02664295,0.0004555685,0.001441032,0.001142638,0.004091362,0.000593564,0.433229,0.5282686,0.0007941235],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.000125032,0.01162851,0.01651947,0.9428288,0.02664994,0.0002924508,0.0001603169,0.0001698252,0.001625695],"genre_scores_gemma":[0.004286426,0.00900627,0.05353959,0.8485579,0.08109982,0.001893662,0.0002492176,0.0002999259,0.001067171],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2290506,"threshold_uncertainty_score":0.2824603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8534718288419137,"score_gpt":0.5669957380861,"score_spread":0.2864760907558137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}