{"id":"W4311125416","doi":"10.1186/s12885-022-10359-z","title":"Detection and genomic analysis of BRAF fusions in Juvenile Pilocytic Astrocytoma through the combination and integration of multi-omic data","year":2022,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; SickKids Foundation; Montreal Neurological Institute and Hospital; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; McGill University Health Centre; Alberta Children's Hospital; McGill University; University of Calgary; Jewish General Hospital; McGill Genome Centre","funders":"Fonds de Recherche du Québec - Santé; Fondation Charles-Bruneau; Canada Foundation for Innovation; Government of Ontario; Government of Canada; Ontario Institute for Cancer Research; Canadian Institutes of Health Research; Genome Canada; McGill University","keywords":"Transcriptome; Biology; Astrocytoma; Computational biology; Pilocytic astrocytoma; Fusion gene; Gene; Genome; RNA-Seq; Cancer research; Bioinformatics; Genetics; Glioma; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006320504,0.0005512299,0.0005548571,0.002429836,0.0005675566,0.0009845796,0.0003863062,0.0006456172,0.00101126],"category_scores_gemma":[0.001371775,0.0002486648,0.0008558733,0.001691166,0.0003173433,0.000354014,0.001043995,0.0006872991,0.0005907904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004816816,"about_ca_system_score_gemma":0.0006365739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002397162,"about_ca_topic_score_gemma":0.007273674,"domain_scores_codex":[0.9993027,0.00005841039,0.00004304325,0.0003100613,0.000202477,0.00008321043],"domain_scores_gemma":[0.9991191,0.0002969994,0.0002372392,0.00009101272,0.0001717016,0.00008392236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005923507,0.0001097893,0.1193751,0.002112322,0.0007759891,0.001618647,0.0006043553,0.006795319,0.8101392,0.001107353,0.004778777,0.05199082],"study_design_scores_gemma":[0.00006328076,0.0004064919,0.6518345,0.0004465006,0.001362613,0.004797263,0.001478692,0.05009708,0.2037687,0.006268606,0.07927948,0.0001967574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8456239,0.006254057,0.04764961,0.0006181475,0.000131302,0.0001466397,0.09291354,0.002266644,0.004396108],"genre_scores_gemma":[0.7925075,0.002304644,0.08939224,0.0006586601,0.00009214813,0.0002798172,0.1128424,0.0006636254,0.001259067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002429836,"threshold_uncertainty_score":0.004766464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06220071700630037,"score_gpt":0.3295671898422557,"score_spread":0.2673664728359553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}