{"id":"W4311128389","doi":"10.1002/mus.27768","title":"Oral edaravone demonstrated a favorable safety profile in patients with amyotrophic lateral sclerosis after 48 weeks of treatment","year":2022,"lang":"en","type":"article","venue":"Muscle & Nerve","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Mitsubishi Tanabe Pharma Corporation","keywords":"Tolerability; Medicine; Adverse effect; Edaravone; Amyotrophic lateral sclerosis; Anesthesia; Constipation; Internal medicine; Surgery; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005862545,0.0002811294,0.0008606411,0.000102586,0.0001608242,0.0002655061,0.0001625298,0.0003640575,0.001689668],"category_scores_gemma":[0.0008199321,0.0001233216,0.0004591645,0.0001568836,0.0001587066,0.0002289804,0.0001138371,0.0006317947,0.0002565604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002111714,"about_ca_system_score_gemma":0.0002948129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002877805,"about_ca_topic_score_gemma":0.0006958801,"domain_scores_codex":[0.999823,0.00006641684,0.00001762061,0.00002856019,0.00003535596,0.00002895433],"domain_scores_gemma":[0.9996383,0.0001242058,0.0001131004,0.00002643281,0.00004988131,0.00004806284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1759217,0.006565422,0.05372036,0.002276562,0.002368306,0.002186378,0.0007255411,0.002592879,0.1909999,0.0001913579,0.004224652,0.558227],"study_design_scores_gemma":[0.07837833,0.3885026,0.4453338,0.000343101,0.002066266,0.006437168,0.0003240312,0.003799855,0.04585511,0.0003503365,0.02849952,0.0001098245],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923519,0.005706137,0.0004335376,0.0001549054,0.00003354156,0.00009404236,0.000209001,0.00003818869,0.0009785879],"genre_scores_gemma":[0.9981102,0.0007413364,0.0002198278,0.0001400082,0.00002760824,0.00005233132,0.0002007006,0.000005702197,0.0005023852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001689668,"threshold_uncertainty_score":0.005652547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01967991763514055,"score_gpt":0.2404311529397075,"score_spread":0.2207512353045669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}