{"id":"W4311137624","doi":"10.1161/circulationaha.122.061934","title":"Placental Inflammation Leads to Abnormal Embryonic Heart Development","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Cancer Research UK; British Heart Foundation; Francis Crick Institute; Wellcome Trust; Medical Research Council; Barts Charity; Queen Mary University of London","keywords":"Embryonic heart; Embryonic stem cell; Inflammation; Medicine; Immune system; Offspring; Placentation; Cardiac function curve; Immunology; Placenta; Embryogenesis; Heart development; Biology; Heart disease; Andrology; Pathology; Pregnancy; Internal medicine; Fetus; Cell biology; Heart failure; Embryo; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003290755,0.00043271,0.0002592833,0.0004520126,0.0001734335,0.0004057863,0.000240249,0.0003610722,0.002746308],"category_scores_gemma":[0.0003028204,0.0002405369,0.0003218855,0.0001324591,0.0004540304,0.0001812896,0.0004483327,0.0008505413,0.0003519311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00042362,"about_ca_system_score_gemma":0.0002414673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002275049,"about_ca_topic_score_gemma":0.0003969935,"domain_scores_codex":[0.9996314,0.00007936049,0.00004121898,0.00009973668,0.00008543712,0.00006278986],"domain_scores_gemma":[0.9995825,0.00008279418,0.0001942603,0.00005598482,0.00001963637,0.00006490488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00034526,0.0000523944,0.001152089,0.00009419855,0.00001530686,0.000563468,0.00004261374,0.00008945543,0.9949732,0.0003301656,0.00008693865,0.002254842],"study_design_scores_gemma":[0.0000796571,0.001471388,0.02971738,0.00006635927,0.0001052611,0.003855374,0.0001409208,0.001358139,0.9550598,0.0004895124,0.007640743,0.00001539687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819313,0.005709182,0.008140962,0.000261905,0.00009771874,0.00008078671,0.0006334267,0.000229526,0.002915144],"genre_scores_gemma":[0.9908394,0.002612405,0.003031748,0.0001372574,0.00002383356,0.00007270723,0.00034203,0.0000437918,0.00289685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002746308,"threshold_uncertainty_score":0.009187341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02245254355744511,"score_gpt":0.261653516519895,"score_spread":0.2392009729624499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}